Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710069, Shaanxi, People's Republic of China.
J Mater Chem B. 2019 Apr 28;7(16):2626-2633. doi: 10.1039/c9tb00195f. Epub 2019 Mar 20.
Real-time monitoring of wound pH may provide information about the wound healing status and potential bacterial infection. Herein, we integrated the biocompatible color changing substance curcumin into a fibrous material, capable of in situ real-time visually monitoring the wound pH. The results indicate that the curcumin-loaded fibrous mat exhibits an obvious pH-dependent color change from yellow to red brown with a change in pH from 6.0 to 9.0, which can be easily detected by the human naked eye. Moreover, the wound pH conditions can be determined with the aid of a smart phone App after image analysis. Due to their flexibility, the fibrous materials have been further processed into various shapes from 1D to 3D for fitting the irregular wounds. It is believed that smart fibrous materials that can simultaneously real-time monitor the wound pH and repair the wound may change wound management to a convenient and comfortable way.
实时监测伤口 pH 值可能提供有关伤口愈合状态和潜在细菌感染的信息。在此，我们将生物相容性的变色物质姜黄素整合到一种纤维材料中，使其能够原位实时直观监测伤口 pH 值。结果表明，负载姜黄素的纤维垫在 pH 值从 6.0 到 9.0 变化时，表现出明显的 pH 值依赖性颜色变化，从黄色变为红棕色，这种颜色变化可以用肉眼轻松检测到。此外，借助智能手机应用程序进行图像分析后，可以确定伤口 pH 值条件。由于其柔韧性，纤维材料已进一步加工成从 1D 到 3D 的各种形状，以适应不规则的伤口。人们相信，能够同时实时监测伤口 pH 值并修复伤口的智能纤维材料，可以将伤口管理转变为一种方便舒适的方式。
