Institut Galien Paris Sud, Univ Paris-Sud, CNRS, Université Paris-Saclay, 92296 Châtenay-Malabry, France.
J Mater Chem B. 2019 Mar 21;7(11):1805-1823. doi: 10.1039/c9tb00015a. Epub 2019 Feb 18.
Light-responsive liposomes are considered nowadays as one of the most promising nanoparticulate systems for the delivery and release of an active pharmaceutical ingredient (API) in a spatio-temporal manner. Several strategies can be used to design photo-triggered liposomes. One of them consists in the incorporation of a photosensitizer (PS) in the lipid matrix of a liposomal bilayer that induces the release of the cargo either via a photochemical or a photophysical process. Among the described photosensitizers, porphyrin derivatives have appeared as the most potent ones. This review describes the state-of-the-art of photo-triggerable liposomes based on the combination of lipids and porphyrin derivatives either free or conjugated. It focuses on the different light-triggered release mechanisms and the requirements for the development of such systems. It also details the different strategies for the synthesis of lipid-porphyrin conjugates, their self-assembling properties and their biomedical applications.
光响应脂质体被认为是目前最有前途的纳米颗粒系统之一，可用于以时空方式递送和释放活性药物成分 (API)。可以使用几种策略来设计光触发脂质体。其中一种方法是将光敏剂 (PS) 掺入脂质双层的脂质基质中，通过光化学或光物理过程诱导货物释放。在所描述的光敏剂中，卟啉衍生物已成为最有效的光敏剂之一。本综述描述了基于脂质和游离或缀合的卟啉衍生物组合的光触发脂质体的最新进展。它重点介绍了不同的光触发释放机制以及开发此类系统的要求。它还详细介绍了合成脂质-卟啉缀合物的不同策略、它们的自组装特性及其在生物医学中的应用。
