褪黑素在接受非手术牙周治疗的2型糖尿病伴牙周病患者中的抗氧化和抗炎特性：一项双盲、安慰剂对照试验
Antioxidant and Anti-Inflammatory Properties of Melatonin in Patients with Type 2 Diabetes Mellitus with Periodontal Disease Under Non-Surgical Periodontal Therapy: A Double-Blind, Placebo-Controlled Trial.
作者信息
Zare Javid Ahmad, Hosseini Seyed Ahmad, Gholinezhad Hassan, Moradi Leila, Haghighi-Zadeh Mohammad Hosein, Bazyar Hadi
机构信息
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Diabetes Metab Syndr Obes. 2020 Mar 18;13:753-761. doi: 10.2147/DMSO.S242208. eCollection 2020.
BACKGROUND AND AIM
The imbalance between pro-oxidant and antioxidant systems often leads to further oxidative damage in the pathogenesis of both diabetes and periodontal disease. This study aimed to investigate the antioxidant and anti-inflammatory properties of melatonin in type 2 diabetes mellitus (T2DM) patients with periodontal disease (PD) under non-surgical periodontal therapy (NSPT).
MATERIALS AND METHODS
In this double-blind clinical trial study, 50 T2DM patients with PD were randomly allocated to intervention and control groups and received 250 mg/day (2 tablets) either melatonin or placebo 1 h before bedtime for 8 weeks. The NSPT was performed for all patients in both groups at the beginning of the study. The serum levels of interleukin-1b (IL-1b), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were measured pre- and post-intervention.
RESULTS
Supplementation with melatonin in adjunct to NSPT significantly increased the serum levels of TAC, SOD, CAT, and GPx in the intervention group (P = 0.02, 0.008, 0.004 and 0.004, respectively). The mean changes of SOD, CAT, and GPx were significantly (P = 0.02, 0.04 and 0.04, respectively) greater in the intervention group compared with the control group. Also, after adjusting for confounding factors, the results did not change in terms of significance (P < 0.05). After the intervention, serum levels of MDA and IL-1b were significantly reduced in the intervention group (P < 0.001 and P = 0.008, respectively). The intervention group exhibited lower mean changes of MDA compared with the control group, and these changes were statistically significant (P = 0.008). In addition, after adjusting for confounding factors, the results did not change in terms of significance.
CONCLUSION
The adjunctive effects of melatonin and NSPT may improve inflammatory and antioxidant parameters in T2DM patients with PD.
背景与目的
在糖尿病和牙周病的发病机制中，促氧化剂和抗氧化剂系统之间的失衡常常导致进一步的氧化损伤。本研究旨在调查褪黑素在非手术牙周治疗（NSPT）下对2型糖尿病（T2DM）合并牙周病（PD）患者的抗氧化和抗炎特性。
材料与方法
在这项双盲临床试验研究中，50名T2DM合并PD患者被随机分为干预组和对照组，在睡前1小时分别服用250毫克/天（2片）褪黑素或安慰剂，持续8周。两组所有患者在研究开始时均接受NSPT。在干预前后测量血清白细胞介素-1β（IL-1β）、丙二醛（MDA）、总抗氧化能力（TAC）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）水平。
结果
在干预组中，NSPT联合补充褪黑素显著提高了血清TAC、SOD、CAT和GPx水平（分别为P = 0.02、0.008、0.004和0.004）。与对照组相比，干预组SOD、CAT和GPx的平均变化显著更大（分别为P = 0.02、0.04和0.04）。此外，在调整混杂因素后，结果在显著性方面没有变化（P < 0.05）。干预后，干预组血清MDA和IL-1β水平显著降低（分别为P < 0.001和P = 0.008）。与对照组相比，干预组MDA的平均变化较低，且这些变化具有统计学意义（P = 0.008）。此外，在调整混杂因素后，结果在显著性方面没有变化。
结论
褪黑素和NSPT的辅助作用可能改善T2DM合并PD患者的炎症和抗氧化参数。
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