补充生姜对非手术牙周治疗的2型糖尿病合并慢性牙周炎患者炎症、抗氧化及牙周参数的影响。一项双盲、安慰剂对照试验。
The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial.
作者信息
Zare Javid Ahmad, Bazyar Hadi, Gholinezhad Hasan, Rahimlou Mehran, Rashidi Homeira, Salehi Parvin, Haghighi-Zadeh Mohammad Hosein
机构信息
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Diabetes Metab Syndr Obes. 2019 Sep 6;12:1751-1761. doi: 10.2147/DMSO.S214333. eCollection 2019.
BACKGROUND
The aim of this study was to evaluate the effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus (T2DM) patients with chronic periodontitis (CP) under non-surgical periodontal therapy (NSPT).
MATERIAL AND METHODS
In this double-blind clinical trial study, 46 T2DM patients with CP were randomly allocated to intervention and control groups and received either 4 tablets 500 mg (2 g) ginger or placebo twice a day for 8 weeks. All patients were treated with NSPT during the intervention period. Serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), hs-C-reactive protein (hs-CRP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), periodontal indices including clinical attachment loss (CAL), bleeding on probing (BOP), pocket depth (PD), and plaque index were evaluated in all subjects pre- and post-intervention.
RESULTS
Following 8 weeks of ginger treatment with NSPT, significant reductions were observed in the mean levels of IL-6 (=0.001), hs-CRP (=0.03), TNF-α (=0.007), CAL, and PD (<0.001) in the intervention group. The mean serum levels of SOD and GPx were significantly increased in the intervention group after the intervention (=0.001 and 0.002, respectively). At the end of the study, the mean changes of GPx were significantly higher in the intervention group compared with the control group (=0.04). Also, after the administration of the ginger with NSPT, significant decrease occurred in the mean change of IL-6 (=0.009), hs-CRP (=0.049), TNF-α (=0.049), CAL (=0.003), and PD (=0.04) compared with the control group.
CONCLUSION
It is recommended that ginger supplementation along with NSPT may be effective in the improvement of inflammation, oxidative, and periodontal status in T2DM with CP.
背景
本研究旨在评估在非手术牙周治疗（NSPT）下，补充生姜对2型糖尿病（T2DM）合并慢性牙周炎（CP）患者的炎症、抗氧化和牙周参数的影响。
材料与方法
在这项双盲临床试验研究中，46例T2DM合并CP患者被随机分为干预组和对照组，干预组每天服用4片500毫克（2克）生姜，对照组服用安慰剂，持续8周。在干预期内，所有患者均接受NSPT治疗。在干预前后，对所有受试者的血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）水平以及包括临床附着丧失（CAL）、探诊出血（BOP）、牙周袋深度（PD）和菌斑指数在内的牙周指标进行评估。
结果
在接受生姜治疗并联合NSPT 8周后，干预组的IL-6（=0.001）、hs-CRP（=0.03）、TNF-α（=0.007）、CAL和PD（<0.001）的平均水平显著降低。干预后，干预组的血清SOD和GPx平均水平显著升高（分别为=0.001和0.002）。在研究结束时，干预组的GPx平均变化显著高于对照组（=0.04）。此外，与对照组相比，在联合NSPT服用生姜后，IL-6（=0.009）、hs-CRP（=0.049）、TNF-α（=0.049）、CAL（=0.003）和PD（=0.04）的平均变化显著降低。
结论
建议在NSPT的基础上补充生姜可能对改善T2DM合并CP患者的炎症、氧化和牙周状况有效。
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