The Long Non-coding RNA lnc-DMP1 Regulates Expression Through H3K27Ac Modification.

Several long non-coding RNAs (lncRNAs) have been reported regulate the expression of neighbor protein-coding genes at post-transcriptional, transcriptional and epigenetic levels. (), encoding a non-collagenous extracellular matrix protein, plays an important role in dentin and bone mineralization. However, the transcriptional regulation of lncRNA on has not been reported. In this study, we identified a novel lncRNA named lnc-DMP1, which is near the gene region and undergoes remarkable changes during mandible development. lnc-DMP1 is co-localized and significantly expressed correlation with in embryonic and postnatal mouse mandibles. In MC3T3-E1 cells, lnc-DMP1 positively regulates DMP1 expression and skeletal mineralization. Furthermore, lnc-DMP1 induces the promoter activity of by modulating H3K27Ac enrichment in the promoter. In conclusion, our results indicate that lnc-DMP1 is a novel lncRNA near the gene region and regulates expression by modulating the H3K27 acetylation level of promoter.