• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从……中提取的多糖通过调节肠道微生物群的组成减轻小鼠高脂饮食诱导的肥胖。 （你提供的原文中“from”后面缺少具体内容）

Polysaccharide extracted from reduces high-fat diet-induced obesity in mice by regulating the composition of intestinal microbiota.

作者信息

Wang Wendong, Zhong Mintao, Yu Tiantian, Chen Lei, Shi Lijun, Zong Junwei, Wang Shouyu

机构信息

1Department of Orthopedic Surgery, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, China.

2College of Integrative Medicine, Dalian Medical University, 9 South Lushun Road West, Dalian, China.

出版信息

Nutr Metab (Lond). 2020 Mar 30;17:27. doi: 10.1186/s12986-020-00442-2. eCollection 2020.

DOI:10.1186/s12986-020-00442-2
PMID:32256675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7106597/
Abstract

BACKGROUND

Obesity is a severe public health threat worldwide. Emerging evidence suggests that gut microbiota dysbiosis is closely associated with obesity and its related metabolic complications. The aim of the present study is to investigate the effects of polysaccharide extracted from (PEW) on high-fat diet (HFD)-induced obesity, and the potential mechanisms involving modulation of the gut microbiota composition.

METHODS

Mice were fed a normal chow diet and a high-fat diet with or without PEW (300 mg/kg/day) by oral gavage for 8 weeks. Body weight, obesity-related metabolic disorders, and gut microbiota were examined at the end of the experiment.

RESULTS

PEW supplementation reduces body weight, adipose hypertrophy, liver steatosis, insulin resistance and systemic inflammation in HFD-fed mice, as well as maintains intestinal epithelium integrity. High-throughput 16S rRNA analysis demonstrates that PEW supplementation alters the composition of gut microbiota. The to ratio and the relative abundance of are increased in HFD-fed mice, which are reversed by PEW supplementation to approximately the control levels.

CONCLUSIONS

Our results suggest that PEW may be used as a bioactive ingredient to prevent obesity and its related metabolic disorders by modulating the composition of gut microbiota.

摘要

背景

肥胖是全球范围内严重的公共卫生威胁。新出现的证据表明，肠道微生物群失调与肥胖及其相关代谢并发症密切相关。本研究的目的是探讨从[具体来源]提取的多糖（PEW）对高脂饮食（HFD）诱导的肥胖的影响，以及涉及调节肠道微生物群组成的潜在机制。

方法

将小鼠分为正常饮食组和高脂饮食组，高脂饮食组小鼠通过口服灌胃给予或不给予PEW（300mg/kg/天），持续8周。在实验结束时检测体重、肥胖相关代谢紊乱和肠道微生物群。

结果

补充PEW可减轻高脂饮食喂养小鼠的体重、脂肪肥大、肝脏脂肪变性、胰岛素抵抗和全身炎症，并维持肠道上皮完整性。高通量16S rRNA分析表明，补充PEW会改变肠道微生物群的组成。高脂饮食喂养小鼠的[具体菌属比例]和[具体菌属名称]的相对丰度增加，而补充PEW可将其逆转至接近对照水平。

结论

我们的结果表明，PEW可能作为一种生物活性成分，通过调节肠道微生物群的组成来预防肥胖及其相关代谢紊乱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/0edf50dc07c3/12986_2020_442_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/8d756d18a0e4/12986_2020_442_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/ff883ae5e6c0/12986_2020_442_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/65420af1c2d3/12986_2020_442_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/ed585d590ee0/12986_2020_442_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/f0c2d20b9cc4/12986_2020_442_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/76953c4a101d/12986_2020_442_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/0edf50dc07c3/12986_2020_442_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/8d756d18a0e4/12986_2020_442_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/ff883ae5e6c0/12986_2020_442_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/65420af1c2d3/12986_2020_442_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/ed585d590ee0/12986_2020_442_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/f0c2d20b9cc4/12986_2020_442_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/76953c4a101d/12986_2020_442_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b54/7106597/0edf50dc07c3/12986_2020_442_Fig7_HTML.jpg

相似文献

1
Polysaccharide extracted from reduces high-fat diet-induced obesity in mice by regulating the composition of intestinal microbiota.从……中提取的多糖通过调节肠道微生物群的组成减轻小鼠高脂饮食诱导的肥胖。 （你提供的原文中“from”后面缺少具体内容）
Nutr Metab (Lond). 2020 Mar 30;17:27. doi: 10.1186/s12986-020-00442-2. eCollection 2020.
2
Melatonin prevents obesity through modulation of gut microbiota in mice.褪黑素通过调节小鼠肠道微生物群预防肥胖。
J Pineal Res. 2017 May;62(4). doi: 10.1111/jpi.12399. Epub 2017 Mar 10.
3
Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice.红肉火龙果花青素通过调节小鼠肠道微生物群，预防饮食诱导的肥胖、肝脏脂肪变性和胰岛素抵抗。
J Gastroenterol Hepatol. 2016 Aug;31(8):1462-9. doi: 10.1111/jgh.13278.
4
Whole mung bean (Vigna radiata L.) supplementation prevents high-fat diet-induced obesity and disorders in a lipid profile and modulates gut microbiota in mice.全绿豆（Vigna radiata L.）补充剂可预防高脂肪饮食引起的肥胖和脂质谱紊乱，并调节小鼠肠道微生物群。
Eur J Nutr. 2020 Dec;59(8):3617-3634. doi: 10.1007/s00394-020-02196-2. Epub 2020 Feb 11.
5
Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice.蜜橘素通过调节高脂饮食诱导肥胖 C57BL/6 小鼠的全身炎症、脂肪褐变和肠道微生物群来预防肥胖。
J Nutr Biochem. 2022 Mar;101:108943. doi: 10.1016/j.jnutbio.2022.108943. Epub 2022 Jan 10.
6
Curcumin alleviates high-fat diet-induced hepatic steatosis and obesity in association with modulation of gut microbiota in mice.姜黄素通过调节肠道微生物群缓解高脂饮食诱导的小鼠肝脂肪变性和肥胖。
Food Res Int. 2021 May;143:110270. doi: 10.1016/j.foodres.2021.110270. Epub 2021 Mar 9.
7
Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.樟芝可降低肥胖小鼠的体重，并调节其肠道微生物菌群。
Int J Obes (Lond). 2018 Feb;42(2):231-243. doi: 10.1038/ijo.2017.149. Epub 2017 Jun 20.
8
A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota.槲皮素和白藜芦醇的组合通过调节肠道微生物群减少高脂肪饮食喂养的大鼠肥胖。
Food Funct. 2017 Dec 13;8(12):4644-4656. doi: 10.1039/c7fo01383c.
9
Gut microbiota mediates the protective effects of dietary β-hydroxy-β-methylbutyrate (HMB) against obesity induced by high-fat diets.肠道微生物群介导膳食 β-羟基-β-甲基丁酸（HMB）对高脂肪饮食诱导肥胖的保护作用。
FASEB J. 2019 Sep;33(9):10019-10033. doi: 10.1096/fj.201900665RR. Epub 2019 Jun 5.
10
The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.橄榄（Olea europaea L.）叶提取物在饮食诱导肥胖的小鼠中的代谢和血管保护作用与改善肠道微生物群落失调及其免疫调节特性有关。
Pharmacol Res. 2019 Dec;150:104487. doi: 10.1016/j.phrs.2019.104487. Epub 2019 Oct 11.

引用本文的文献

1
Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages.脆弱拟杆菌通过分泌细胞外囊泡诱导M2巨噬细胞来加剧2型糖尿病血管钙化。
Adv Sci (Weinh). 2025 Feb;12(5):e2410495. doi: 10.1002/advs.202410495. Epub 2024 Dec 12.
2
Protective effects of the bioactive peptide from maggots against skin flap ischemia‒reperfusion injury in rats.蛆生物活性肽对大鼠皮瓣缺血再灌注损伤的保护作用。
Heliyon. 2024 Apr 18;10(9):e29874. doi: 10.1016/j.heliyon.2024.e29874. eCollection 2024 May 15.
3
Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans.

本文引用的文献

1
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review.高脂肪饮食对肠道通透性的负面影响：综述。
Adv Nutr. 2020 Jan 1;11(1):77-91. doi: 10.1093/advances/nmz061.
2
Protein-rich extract of larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities.幼虫富含蛋白质的提取物通过肝脏保护和胰腺β细胞保护活性减轻了链脲佐菌素诱导的2型糖尿病大鼠模型中的代谢紊乱。
J Biosci. 2018 Dec;43(5):969-983.
3
Extract of the Microalga Nitzschia laevis Prevents High-Fat-Diet-Induced Obesity in Mice by Modulating the Composition of Gut Microbiota.
银耳多糖通过肠道共生菌嗜热栖热菌减轻肥胖。
J Adv Res. 2023 Oct;52:203-218. doi: 10.1016/j.jare.2023.08.003. Epub 2023 Aug 5.
4
Maggot extracts chemo-prevent inflammation and tumorigenesis accompanied by changes in the intestinal microbiome and metabolome in AOM/DSS-induced mice.蛆提取物可预防AOM/DSS诱导的小鼠炎症和肿瘤发生，并伴随肠道微生物群和代谢组的变化。
Front Microbiol. 2023 May 2;14:1143463. doi: 10.3389/fmicb.2023.1143463. eCollection 2023.
5
Anti-inflammatory and immunomodulatory effects of polysaccharide extracted from Wuguchong (maggot) on 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.五谷虫（蛆）提取物多糖对2,4-二硝基氯苯诱导的小鼠特应性皮炎的抗炎和免疫调节作用
Front Pharmacol. 2023 Mar 22;14:1119103. doi: 10.3389/fphar.2023.1119103. eCollection 2023.
6
Protective effect of homogeneous polysaccharides of Wuguchong (HPW) on intestinal mucositis induced by 5-fluorouracil in mice.五谷虫均一多糖对小鼠5-氟尿嘧啶诱导的肠道黏膜炎的保护作用
Nutr Metab (Lond). 2022 May 18;19(1):36. doi: 10.1186/s12986-022-00669-1.
7
Naoxintong Capsule Alternates Gut Microbiota and Prevents Hyperlipidemia in High-Fat-Diet Fed Rats.脑心通胶囊改变高脂饮食喂养大鼠的肠道微生物群并预防高脂血症。
Front Pharmacol. 2022 Mar 21;13:843409. doi: 10.3389/fphar.2022.843409. eCollection 2022.
8
Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases.利用天然多糖靶向肠道微生物群：针对高脂饮食诱导的代谢性疾病的有效干预措施
Front Microbiol. 2022 Mar 15;13:859206. doi: 10.3389/fmicb.2022.859206. eCollection 2022.
微藻小新月菱形藻通过调节肠道微生物群落组成预防高脂饮食诱导的肥胖。
Mol Nutr Food Res. 2019 Feb;63(3):e1800808. doi: 10.1002/mnfr.201800808. Epub 2018 Dec 5.
4
Sulfated Polysaccharide from Sea Cucumber and its Depolymerized Derivative Prevent Obesity in Association with Modification of Gut Microbiota in High-Fat Diet-Fed Mice.海参硫酸多糖及其解聚衍生物通过调节高脂饮食喂养小鼠肠道菌群预防肥胖。
Mol Nutr Food Res. 2018 Dec;62(23):e1800446. doi: 10.1002/mnfr.201800446. Epub 2018 Oct 17.
5
Konjaku flour reduces obesity in mice by modulating the composition of the gut microbiota.蒟蒻粉通过调节肠道微生物群落组成来减少小鼠肥胖。
Int J Obes (Lond). 2019 Aug;43(8):1631-1643. doi: 10.1038/s41366-018-0187-x. Epub 2018 Sep 21.
6
Polysaccharide from fermented Momordica charantia L. with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats.发酵苦瓜多糖与植物乳杆菌 NCU116 改善大鼠 2 型糖尿病。
Carbohydr Polym. 2018 Dec 1;201:624-633. doi: 10.1016/j.carbpol.2018.08.075. Epub 2018 Aug 27.
7
Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans.运动改变瘦素和肥胖人群的肠道微生物组成和功能。
Med Sci Sports Exerc. 2018 Apr;50(4):747-757. doi: 10.1249/MSS.0000000000001495.
8
Mechanisms, Pathophysiology, and Management of Obesity.肥胖的机制、病理生理学及管理
N Engl J Med. 2017 Apr 13;376(15):1492. doi: 10.1056/NEJMc1701944.
9
Melatonin prevents obesity through modulation of gut microbiota in mice.褪黑素通过调节小鼠肠道微生物群预防肥胖。
J Pineal Res. 2017 May;62(4). doi: 10.1111/jpi.12399. Epub 2017 Mar 10.
10
Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.通过蒙脱土吸附-排泄轴重塑微生物组可预防肥胖相关代谢紊乱。
EBioMedicine. 2017 Feb;16:251-261. doi: 10.1016/j.ebiom.2017.01.019. Epub 2017 Jan 18.