Miao Chen-Yun, Fang Xiao-Jie, Chen Yun, Zhang Qin
Third Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.
Department of Anorectal Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang 310000, P.R. China.
Exp Ther Med. 2020 Apr;19(4):2641-2649. doi: 10.3892/etm.2020.8525. Epub 2020 Feb 11.
The aim of the present meta-analysis was to evaluate the effect of vitamin D supplementation on patients with polycystic ovary syndrome (PCOS). A literature search was performed to identify all of the relevant studies comparing the effect of vitamin D supplementation with placebo in PCOS patients, in the PubMed, Embase and Web of Science databases. All statistical analyses were performed on case-control studies using Review Manager 5.3 software, provided by the Cochrane Collaboration. A total of 11 studies involving 483 participants were included in the current meta-analysis. Vitamin D supplementation appeared to lead to an improvement in the levels of total testosterone [weighted mean differences (WMD) = -0.10, 95% CI (-0.18, -0.02)], homeostasis model assessment of insulin resistance [WMD = -0.44, 95% CI (-0.86, -0.03)], homeostasis model assessment of β-cell function [WMD = -16.65, 95% CI (-19.49, -13.80)], total cholesterol [WMD = -11.90, 95% CI (-15.67, -8.13)] and low-density lipoprotein-cholesterol [WMD = -4.54; 95% CI (-7.29, -1.80)]. The results failed to show a positive effect of vitamin D supplementation on the body mass index, dehydroepiandrosterone sulfate, triglyceride levels or high-density lipoprotein-cholesterol. In conclusion, the data from the available randomized controlled trials (RCTs) suggested vitamin D supplementation reduced insulin resistance and hyperandrogenism, as well improving the lipid metabolism of patients with PCOS to an extent. Further high-quality RCTs from a variety of regions in the world are required to determine the effectiveness of vitamin D supplementation in PCOS patients, and to determine a suitable dose and unit of vitamin D.
本荟萃分析的目的是评估补充维生素D对多囊卵巢综合征（PCOS）患者的影响。我们在PubMed、Embase和Web of Science数据库中进行了文献检索，以找出所有比较补充维生素D与安慰剂对PCOS患者影响的相关研究。所有统计分析均使用Cochrane协作网提供的Review Manager 5.3软件，对病例对照研究进行。本荟萃分析共纳入11项研究，涉及483名参与者。补充维生素D似乎能使总睾酮水平得到改善[加权平均差（WMD）=-0.10，95%置信区间（-0.18，-0.02）]、胰岛素抵抗的稳态模型评估[WMD=-0.44，95%置信区间（-0.86，-0.03）]、β细胞功能的稳态模型评估[WMD=-16.65，95%置信区间（-19.49，-13.80）]、总胆固醇[WMD=-11.90，95%置信区间（-15.67，-8.13）]和低密度脂蛋白胆固醇[WMD=-4.54；95%置信区间（-7.29，-1.80）]。结果未显示补充维生素D对体重指数、硫酸脱氢表雄酮、甘油三酯水平或高密度脂蛋白胆固醇有积极影响。总之，现有随机对照试验（RCT）的数据表明，补充维生素D可降低胰岛素抵抗和高雄激素血症，并在一定程度上改善PCOS患者的脂质代谢。需要来自世界不同地区的进一步高质量RCT，以确定补充维生素D对PCOS患者的有效性，并确定合适的维生素D剂量和单位。
