Gurbani Saumya S, Weinberg Brent D, Salgado Eric, Voloschin Alfredo, Velazquez Vega Jose Enrique, Olson Jeffrey J, Shu Hui-Kuo G, Shim Hyunsuk
Department of Radiation Oncology, Emory University, Atlanta, GA, USA.
Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Oxf Med Case Reports. 2020 Mar 30;2020(3):omaa006. doi: 10.1093/omcr/omaa006. eCollection 2020 Mar.
Secondary glioblastoma is a rare brain tumor characterized by a mutation in isocitrate dehydrogenase, which is reported to lead to epigenetic modification. Patients with secondary glioblastoma experience poor survival and quality-of-life outcomes due to the disease's aggressiveness and a lack of targeted therapies. In this report, a patient with a secondary glioblastoma was treated with a histone deacetylase inhibitor, an epigenetic drug with potent anti-inflammatory properties, in addition to the standard regimen. The patient showed very favorable survival and quality-of-life measures, and a restoration of several neuro-metabolites as measured by spectroscopic magnetic resonance imaging.
继发性胶质母细胞瘤是一种罕见的脑肿瘤，其特征是异柠檬酸脱氢酶发生突变，据报道该突变会导致表观遗传修饰。由于该疾病的侵袭性以及缺乏靶向治疗方法，继发性胶质母细胞瘤患者的生存和生活质量预后较差。在本报告中，一名继发性胶质母细胞瘤患者除接受标准治疗方案外，还接受了组蛋白去乙酰化酶抑制剂治疗，这是一种具有强大抗炎特性的表观遗传药物。该患者在生存和生活质量方面表现出非常良好的指标，并且通过磁共振波谱成像测量发现多种神经代谢物得到了恢复。
