Yang Yibo, Li Tianyi, Li Zhibo, Liu Ning, Yan Youyou, Liu Bin
Department of Cardiology, The Second Hospital of Jilin University, Changchun 130041, China.
Aging Dis. 2020 Mar 9;11(2):419-437. doi: 10.14336/AD.2019.0518. eCollection 2020 Apr.
Cardiovascular disease is the leading cause of mortality worldwide, and mitochondrial dysfunction is the primary contributor to these disorders. Recent studies have elaborated on selective autophagy-mitophagy, which eliminates damaged and dysfunctional mitochondria, stabilizes mitochondrial structure and function, and maintains cell survival and growth. Numerous recent studies have reported that mitophagy plays an important role in the pathogenesis of various cardiovascular diseases. This review summarizes the mechanisms underlying mitophagy and advancements in studies on the role of mitophagy in cardiovascular disease.
心血管疾病是全球主要的死亡原因，而线粒体功能障碍是这些疾病的主要促成因素。最近的研究阐述了选择性自噬——线粒体自噬，它能清除受损和功能失调的线粒体，稳定线粒体结构和功能，并维持细胞存活和生长。最近大量研究报告称，线粒体自噬在各种心血管疾病的发病机制中起重要作用。本综述总结了线粒体自噬的潜在机制以及线粒体自噬在心血管疾病中作用的研究进展。
