Asuquo Ikanna E, Edagha Innocent A, Ekandem Gabriel J, Peter Aniekan I
Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, PMB 1017, Uyo, 520001 Nigeria.
Toxicol Res. 2019 Nov 21;36(2):149-157. doi: 10.1007/s43188-019-00017-1. eCollection 2020 Apr.
Chronic alcohol consumption has been implicated in male infertility, whereas (CP) ripe fruit possesses antioxidant activity. This study investigated histomorphological and hormonal effects of ripened CP in alcohol experimental model. Thirty Wistar rats were divided into six groups of five animals each as follows; groups 1, 2 and 3 received distilled water 2 ml, 40% ethanol 5 ml, and 40% ethanol 5 ml + 50 mg Clomiphene citrate/kg body weight, respectively, while groups 4, 5 and 6 received 40% ethanol 5 ml + CP 500, 1000 and 1500 mg/kg body weight, respectively. Sperm counts and motility were significantly decreased ( < 0.05) in group 2 compared to group 1. Testosterone significantly increased ( < 0.05) in CP-treated groups, and luteinizing hormone was significantly reduced ( < 0.05) compared to the control. Group 2 showed spermatogenic cell distortions which were ameliorated in the CP-treated groups. CP exerted testicular protective potential against ethanol-induced testicular toxicity plausibly via its antioxidant mechanism.
长期饮酒与男性不育有关，而（CP）成熟果实具有抗氧化活性。本研究在酒精实验模型中研究了成熟CP的组织形态学和激素效应。将30只Wistar大鼠分为六组，每组五只动物，分组如下：第1、2和3组分别接受2毫升蒸馏水、5毫升40%乙醇以及5毫升40%乙醇+50毫克枸橼酸氯米芬/千克体重，而第4、5和6组分别接受5毫升40%乙醇+500、1000和1500毫克/千克体重的CP。与第1组相比，第2组的精子数量和活力显著降低（<0.05）。CP治疗组的睾酮显著升高（<0.05），与对照组相比，促黄体生成素显著降低（<0.05）。第2组出现生精细胞畸变，而在CP治疗组中得到改善。CP可能通过其抗氧化机制对乙醇诱导的睾丸毒性发挥睾丸保护作用。
