Chen Ling, Wu Lin, Liu Fei, Qi Xueyong, Ge Yanru, Shen Song
College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
J Mater Chem B. 2016 Jun 7;4(21):3660-3669. doi: 10.1039/c5tb02704g. Epub 2016 May 3.
To improve the therapeutic effect and decrease the toxicity in normal tissues, stimuli-responsive drug delivery systems have attracted extensive attention in tumor therapy. In this work, we present a smart drug delivery system based on the stimulated decomposition of a thermo-sensitive molecule, azobis[N-(2-carboxyethyl)-2-methylpropionamidine] (Azo), for the combined photothermal therapy and chemotherapy. Doxorubicin (DOX) was attached to the surface of magnetic nanoparticles (NPs) via the Azo linker. Upon irradiation with near infrared (NIR) light, local heating is generated by iron oxide nanoparticles (IONPs), which triggers the decomposition of the Azo molecule and the release of DOX. Compared with FeO-DOX NPs, FeO-Azo-DOX NPs demonstrate dominant advantages of stability, which results in the low toxicity of FeO-Azo-DOX NPs in cardiac tissues. FeO-Azo NPs display excellent photothermal effects under NIR laser irradiation and extremely low cytotoxicity towards MCF-7 cells. Furthermore, the FeO-Azo-DOX NP system exhibits significantly enhanced cell killing effects upon irradiation with NIR, attributed to the synergistic therapeutic efficacy of photothermal chemotherapy.
为了提高治疗效果并降低正常组织中的毒性，刺激响应型药物递送系统在肿瘤治疗中引起了广泛关注。在这项工作中，我们提出了一种基于热敏分子偶氮双N-(2-羧乙基)-2-甲基丙脒的刺激分解的智能药物递送系统，用于联合光热疗法和化疗。阿霉素(DOX)通过Azo连接体连接到磁性纳米颗粒(NPs)表面。在用近红外(NIR)光照射时，氧化铁纳米颗粒(IONPs)产生局部加热，这触发了Azo分子的分解和DOX的释放。与FeO-DOX NPs相比，FeO-Azo-DOX NPs表现出稳定性方面的显著优势，这导致FeO-Azo-DOX NPs在心脏组织中的低毒性。FeO-Azo NPs在近红外激光照射下表现出优异的光热效应，对MCF-7细胞的细胞毒性极低。此外，FeO-Azo-DOX NP系统在近红外照射下表现出显著增强的细胞杀伤效果，这归因于光热化疗的协同治疗效果。
