Hsu Shan-Hui, Hung Kun-Che, Chen Cheng-Wei
Institute of Polymer Science and Engineering, National Taiwan University, Taipei, Taiwan, ROC.
J Mater Chem B. 2016 Dec 21;4(47):7493-7505. doi: 10.1039/c6tb02176j. Epub 2016 Nov 14.
Tissue engineering aims to repair the damaged tissue by transplantation of cells or introducing bioactive factors in a biocompatible scaffold. In recent years, biodegradable polymer scaffolds mimicking the extracellular matrix have been developed to promote the cell proliferation and extracellular matrix deposition. The biodegradable polymer scaffolds thus act as templates for tissue repair and regeneration. This article reviews the updated information regarding various types of natural and synthetic biodegradable polymers as well as their functions, physico-chemical properties, and degradation mechanisms in the development of biodegradable scaffolds for tissue engineering applications, including their combination with 3D printing.
组织工程旨在通过移植细胞或在生物相容性支架中引入生物活性因子来修复受损组织。近年来，已开发出模仿细胞外基质的可生物降解聚合物支架，以促进细胞增殖和细胞外基质沉积。因此，可生物降解聚合物支架充当组织修复和再生的模板。本文综述了有关各种天然和合成可生物降解聚合物的最新信息，以及它们在用于组织工程应用的可生物降解支架开发中的功能、物理化学性质和降解机制，包括它们与3D打印的结合。
