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基于静电纺丝聚左旋乳酸纳米纤维的用于非侵入式生理信号监测的人体皮肤交互式自供电可穿戴压电生物电子皮肤

Human skin interactive self-powered wearable piezoelectric bio-e-skin by electrospun poly-l-lactic acid nanofibers for non-invasive physiological signal monitoring.

作者信息

Sultana Ayesha, Ghosh Sujoy Kumar, Sencadas Vitor, Zheng Tian, Higgins Michael J, Middya Tapas Ranjan, Mandal Dipankar

机构信息

Organic Nano-Piezoelectric Device Laboratory, Department of Physics, Jadavpur University, Kolkata 700032, India.

出版信息

J Mater Chem B. 2017 Sep 21;5(35):7352-7359. doi: 10.1039/c7tb01439b. Epub 2017 Aug 24.

Abstract

Flexible and wearable piezoelectric bio e-skin (PBio-e-skin) based on electrospun poly(l-lactic acid) PLLA nanofiber membrane is demonstrated for non-invasive human physiological signal monitoring and detecting dynamic tactile stimuli. The molecular orientations of the C[double bond, length as m-dash]O dipoles by electrospinning technique result in a longitudinal piezoelectric charge co-efficient (d) value of ∼(3 ± 1) pm V realized by piezoresponse force microscopy, allowing the PBio-e-skin for pressure sensing applications. The robust mechanical strength (Young's modulus ∼50 MPa) of nanofiber membrane ensures PBio-e-skin's superior operational stability over 375 000 cycles. Owing to the superior mechanosensitivity of ∼22 V N, PBio-e-skin has the ability to measure subtle movement of muscle in the internal organs such as esophagus, trachea, motion of joints and arterial pressure by recognition of strains on human skin. This flexible and light weight PBio-e-skin precisely detects vital signs and provides important clinical insights without using any external power source. Eventually, the low cost, environmental friendly PBio-e-skin will have a huge impact in a broad range of applications including self-powered wearable health care systems, human-machine interfacing devices, artificial intelligence and prosthetic skin.

摘要

基于静电纺丝聚(L-乳酸)(PLLA)纳米纤维膜的柔性可穿戴压电生物电子皮肤(PBio-e-skin)被用于非侵入式人体生理信号监测和动态触觉刺激检测。通过静电纺丝技术使C=O偶极子的分子取向,通过压电力显微镜实现纵向压电电荷系数(d)值约为(3±1)pm V,使PBio-e-skin可用于压力传感应用。纳米纤维膜强大的机械强度(杨氏模量约50 MPa)确保PBio-e-skin在超过375000次循环中具有卓越的操作稳定性。由于约22 V/N的卓越机械灵敏度,PBio-e-skin有能力通过识别人体皮肤上的应变来测量诸如食道、气管等内部器官中肌肉的细微运动、关节运动和动脉血压。这种柔性且轻质的PBio-e-skin无需任何外部电源就能精确检测生命体征并提供重要的临床见解。最终,低成本、环境友好的PBio-e-skin将在包括自供电可穿戴医疗保健系统、人机接口设备、人工智能和假肢皮肤在内的广泛应用中产生巨大影响。

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