基于通过主客体相互作用由半乳糖功能化柱[5]芳烃封端的纳米氧化铈的协同靶向药物递送。
Synergistic and targeted drug delivery based on nano-CeO capped with galactose functionalized pillar[5]arene via host-guest interactions.
作者信息
Wu Xiaowen, Zhang Ying, Lu Yuchao, Pang Shuang, Yang Kui, Tian Zhimin, Pei Yuxin, Qu Yongquan, Wang Feng, Pei Zhichao
机构信息
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, 712100 Shaanxi, P. R. China.
出版信息
J Mater Chem B. 2017 May 21;5(19):3483-3487. doi: 10.1039/c7tb00752c. Epub 2017 May 4.
A smart drug delivery system based on porous CeO nano-rods (CeONRs) capped with galactose functionalized pillar[5]arene via host-guest interactions has been constructed, which showed GSH-responsiveness, synergism with anticancer drugs and cancer targeting ability resulting from its disulphide unit, ceria properties and galactose units, respectively.
基于通过主客体相互作用用半乳糖功能化柱[5]芳烃封端的多孔CeO纳米棒（CeONRs）构建了一种智能药物递送系统，该系统分别因其二硫键单元、二氧化铈性质和半乳糖单元而表现出谷胱甘肽响应性、与抗癌药物的协同作用和癌症靶向能力。
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