Pechook Sasha, Sudakov Kobi, Polishchuk Iryna, Ostrov Ievgeniia, Zakin Varda, Pokroy Boaz, Shemesh Moshe
Department of Materials Science and Engineering, Technion Israel Institute of Technology, 32000 Haifa, Israel.
J Mater Chem B. 2015 Feb 21;3(7):1371-1378. doi: 10.1039/c4tb01522c. Epub 2015 Jan 14.
Biofilm formation enables bacteria to grow under unfavorable conditions, provides them with protection, and increases their resistance to antimicrobial agents. Once a biofilm has formed, it is difficult, and in some systems, impossible to treat. Strategies based on the release of biocidal agents have shown only transient efficiency. Herein, we present a novel bioinspired passive approach to the prevention of surface biofilm attachment by exploiting superhydrophobic surfaces formed via the self-assembly of paraffin or fluorinated wax crystals. Our surfaces show exceptional ability to inhibit biofilm formation of both Gram-positive Bacillus cereus and Gram-negative Pseudomonas aeruginosa over a 7 day period (up to 99.9% inhibition).
生物膜的形成使细菌能够在不利条件下生长，为它们提供保护，并增强它们对抗菌剂的抗性。一旦生物膜形成，就很难治疗，在某些系统中甚至无法治疗。基于释放杀生物剂的策略仅显示出短暂的效果。在此，我们提出一种新型的受生物启发的被动方法，通过利用石蜡或氟化蜡晶体自组装形成的超疏水表面来防止表面生物膜附着。我们的表面显示出在7天时间内抑制革兰氏阳性蜡样芽孢杆菌和革兰氏阴性铜绿假单胞菌生物膜形成的卓越能力（抑制率高达99.9%）。
