Loh Xian Jun, Abdul Karim Anis, Owh Cally
Institute of Materials Research and Engineering (IMRE), A*STAR, 3 Research Link, Singapore 117602, Singapore.
J Mater Chem B. 2015 Oct 21;3(39):7641-7652. doi: 10.1039/c5tb01048a. Epub 2015 Aug 18.
The recently developed poly(glycerol sebacate) (PGS) has been gaining attraction as a biomaterial for tissue engineering applications. Reported in 2002, a simple polycondensation method was developed to synthesize PGS for soft tissue engineering applications. It has since become a highly sought after biomaterial due to its soft, robust and flexible characteristics and it is relatively low cost compared to other biodegradable elastomers currently available in the market. We summarise in this review, the various synthetic approaches of PGS and highlight selected applications in nerve guidance, soft tissue regeneration, vascular and myocardial tissue regeneration, blood vessel reconstruction, drug delivery, and the replacement of photoreceptor cells. A critical assessment of the material is provided as a scope for future improvement. The future outlook of this material is also provided at the end of this review.
最近开发的聚癸二酸甘油酯（PGS）作为一种用于组织工程应用的生物材料正受到越来越多的关注。2002年有报道称，已开发出一种简单的缩聚方法来合成用于软组织工程应用的PGS。此后，由于其柔软、坚固且灵活的特性，它已成为一种备受追捧的生物材料，并且与目前市场上其他可生物降解的弹性体相比，其成本相对较低。在这篇综述中，我们总结了PGS的各种合成方法，并重点介绍了其在神经引导、软组织再生、血管和心肌组织再生、血管重建、药物递送以及光感受器细胞替代等方面的选定应用。对该材料进行了批判性评估，作为未来改进的方向。本文末尾还提供了该材料的未来展望。
