Comparison of Short and Long-Term Outcomes of Metabolic and Bariatric Surgery in Adolescents and Adults.

We sought to compare the short and long-term outcomes of MBS in adolescents vs. adults who have undergone a Roux-en-Y gastric bypass (RYGB) or Sleeve gastrectomy (SG). Retrospective cohort study. Single tertiary care academic referral center. One hundred fifty adolescent (≤ 21-years) and adult (>21-years) subjects with severe obesity between 15 and 70 years of age who underwent RYGB or SG. Metabolic parameters, weight and height measures were obtained pre-and post-surgery (at 3 and 6 months, and then annually for 4 years). Median pre-surgical body mass index (BMI) was higher in adolescents ( = 76) vs. adults ( = 74): 50 (45-57) vs. 44 (40-51) kg/m ( < 0.0001). However, obesity related complications were greater in adults vs. adolescents: 66 vs. 21% had hypertension, 68 vs. 28% had dyslipidemia, and 42 vs. 21% had type 2 diabetes mellitus (all < 0.010). % BMI reduction and % weight loss (WL) were greater in adolescents vs. adults at all time points ( < 0.050). %WL was higher in adolescents who underwent SG at each time point ( < 0.050), and trended higher among adolescents who underwent RYGB ( = 0.060), compared to adults with the respective procedure. Follow-up data showed greater resolution of type 2 diabetes and hypertension in adolescents than adults (87.5 vs. 54.8%; = 0.04, and 68.7 vs. 35.4%; = 0.040). Adolescents compared to adults had greater reductions in BMI and weight, even at 4 years, and greater resolution of type 2 diabetes and hypertension. Earlier intervention in the treatment of severe obesity with MBS may lead to better outcomes.