Irijimasides A-E，一种来自海洋蓝藻的大环糖甙类抗生素。
Irijimasides A-E, Macrolide Glycosides from an sp. Marine Cyanobacterium.
机构信息
Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
Graduate School of Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
出版信息
J Nat Prod. 2020 May 22;83(5):1585-1591. doi: 10.1021/acs.jnatprod.0c00042. Epub 2020 Apr 8.
Irijimasides A-E (-), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of - were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.
Irijimasides A-E(-)，是一组新型的 14 元大环糖甙，从冲绳采集的海洋蓝细菌中分离得到。通过包括 2D NMR 在内的光谱分析，确定了-的结构，而绝对立体结构则是基于 NOESY 谱、化学衍生化和 ECD 数据确定的。所有五种大环内酯均抑制核因子-κB 配体（RANKL）诱导的抗酒石酸酸性磷酸酶（TRAP）活性在小鼠 RAW264 巨噬细胞中，表明这些化合物抑制破骨细胞的形成。
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