从海洋 sp. 蓝细菌中分离和结构确定阿库诺内酯，大环糖苷。
Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine sp. Cyanobacterium.
机构信息
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
出版信息
J Nat Prod. 2023 Nov 24;86(11):2529-2538. doi: 10.1021/acs.jnatprod.3c00742. Epub 2023 Nov 9.
Akunolides A (), B (), C (), and D (), new macrolide glycosides, were isolated from a marine sp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A-D (-) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A-D (-) showed moderate antitrypanosomal activities against , with IC values ranging from 11 to 14 μM. Furthermore, akunolides A () and C () exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.
从海洋 蓝藻中分离得到阿克诺利德 A（）、B（）、C（）和 D（），它们是新的大环内酯糖苷。通过光谱分析和衍生化反应阐明了它们的结构。阿克诺利德 A-D（-）被归类为 16 元大环内酯糖苷，这对于海洋蓝藻来源的天然产物来说是相对罕见的结构。阿克诺利德 A-D（-）对 具有中等的抗变形虫活性，IC 值范围为 11 至 14 μM。此外，阿克诺利德 A（）和 C（）即使在 150 μM 的浓度下对正常人类 WI-38 细胞也没有细胞毒性。
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