Department of Neurology, Ulm University, 89081 Ulm, Germany.
Department of Neurology, University of Halle/Wittenberg, 06120 Halle/S., Germany.
Int J Environ Res Public Health. 2020 Apr 6;17(7):2502. doi: 10.3390/ijerph17072502.
In patients with neuromuscular disorder, only little data of myalgia frequency and characterization exists. To date, only a weak correlation between pain intensity and pressure pain threshold has been found, and it remains enigmatic whether high pain intensity levels are equivalent to high pain sensitivity levels in neuromuscular disorders.
30 sequential patients with suspected neuromuscular disorder and myalgia were analyzed with regard to myalgia characteristics and clinical findings, including symptoms of depression and anxiety and pain- threshold.
A neuromuscular disorder was diagnosed in 14/30 patients. Muscular pain fasciculation syndrome (MPFS) without evidence for myopathy or myositis was diagnosed in 10/30 patients and 6/30 patients were diagnosed with pure myalgia without evidence for a neuromuscular disorder (e.g., myopathy, myositis, MPFS, polymyalgia rheumatica). Highest median pain scores were found in patients with pure myalgia and polymyalgia rheumatica. Pressure pain threshold measurement showed a significant difference between patients and controls in the biceps brachii muscle.
Only a weak correlation between pain intensity and pressure pain threshold has been suggested, which is concordant with our results. The hypothesis that high pain intensity levels are equivalent to high pain sensitivity levels was not demonstrated.
在神经肌肉疾病患者中，仅有少量关于肌痛频率和特征的资料。迄今为止，仅发现疼痛强度与压痛阈值之间存在弱相关性，而在神经肌肉疾病中，高疼痛强度水平是否等同于高疼痛敏感性水平仍然是一个谜。
对 30 例疑似神经肌肉疾病和肌痛的连续患者进行了肌痛特征和临床发现分析，包括抑郁和焦虑症状以及疼痛阈值。
14/30 例患者诊断为神经肌肉疾病。10/30 例患者诊断为肌束颤动综合征（MPFS）而无肌病或肌炎证据，6/30 例患者诊断为单纯肌痛而无神经肌肉疾病证据（例如肌病、肌炎、MPFS、巨细胞性多关节炎）。单纯肌痛和巨细胞性多关节炎患者的疼痛评分最高。肱二头肌压痛阈值测量显示患者与对照组之间存在显著差异。
仅提示疼痛强度与压痛阈值之间存在弱相关性，这与我们的结果一致。高疼痛强度水平等同于高疼痛敏感性水平的假设未得到证实。
