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大气污染能否被认为是意大利北部极高水平的 SARS-CoV-2 致死率的一个协同因素?

Can atmospheric pollution be considered a co-factor in extremely high level of SARS-CoV-2 lethality in Northern Italy?

机构信息

Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, viale Mario Bracci 1, Siena, Italy.

Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde, Denmark.

出版信息

Environ Pollut. 2020 Jun;261:114465. doi: 10.1016/j.envpol.2020.114465. Epub 2020 Apr 4.

Abstract

This paper investigates the correlation between the high level of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) lethality and the atmospheric pollution in Northern Italy. Indeed, Lombardy and Emilia Romagna are Italian regions with both the highest level of virus lethality in the world and one of Europe's most polluted area. Based on this correlation, this paper analyzes the possible link between pollution and the development of acute respiratory distress syndrome and eventually death. We provide evidence that people living in an area with high levels of pollutant are more prone to develop chronic respiratory conditions and suitable to any infective agent. Moreover, a prolonged exposure to air pollution leads to a chronic inflammatory stimulus, even in young and healthy subjects. We conclude that the high level of pollution in Northern Italy should be considered an additional co-factor of the high level of lethality recorded in that area.

摘要

本文研究了严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 致死率与意大利北部大气污染之间的相关性。事实上,伦巴第大区和艾米利亚-罗马涅大区是意大利病毒致死率最高的地区,也是欧洲污染最严重的地区之一。基于这种相关性,本文分析了污染与急性呼吸窘迫综合征的发展以及最终死亡之间可能存在的联系。我们提供的证据表明,生活在污染水平较高地区的人更容易患上慢性呼吸道疾病,并且更容易受到任何感染性因素的影响。此外,长期暴露于空气污染会导致慢性炎症刺激,即使是在年轻和健康的人群中。我们的结论是,意大利北部的高污染水平应被视为该地区高死亡率的一个额外的共同因素。

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