Chen Zesheng, Cheng Zongxue, Wu Yaoyao, Yu Zhecong, Qin Kang, Jiang Caixia, Xu Jue
Department of Chronic and Non-Communicable Disease, Hangzhou Center for Disease Control and Prevention (Hangzhou Health Supervision Institution), 568 Ming-Shi Rd, Hangzhou, 310021, Zhejiang, People's Republic of China.
Sci Rep. 2024 Dec 30;14(1):31887. doi: 10.1038/s41598-024-83388-2.
Ambient air pollution exposure was associated with an increased risk of incident cancer, but few previous studies have focused on the associations between ambient air pollution and nasopharyngeal carcinoma (NPC). Thus, our goal is to examine whether exposure to ambient air pollution in Hangzhou, which includes sulfur dioxide (SO), nitrogen dioxide (NO), and inhalable particles (PM), will have an impact the risk of incident cancer. We collected data on daily ambient air pollution data, climate, and daily incidence of NPC in Hangzhou from Jan 1, 2013, to Dec 31, 2022. We applied a generalized additive model (GAM) based on the Poisson distribution to investigate the effect of ambient air pollution on the risk of incident NPC. The effects of ambient air pollution exposure on NPC were also discussed in subgroups by age, gender, region, and season. A total of 3121 NPC incident cases were included during the study period. We discovered that the risk of incident NPC was increased by 0.75% (95% CI: 0.01-1.58), 0.36% (95% CI: 0.03-0.69), and 0.14% (95% CI: 0.01-0.28) for every 1 μg/m increase in the concentration of SO, NO, and PM, respectively. These pollutants continued to have a substantial impact on the risk of incident NPC even after controlling for other ambient air pollutants. A noteworthy affirmative connection was a significant positive correlation between SO and NPC in male, warm season, urban areas, and elderly subgroups. In contrast to SO, there was a significant positive correlation between PM and NPC in female, warm season, rural areas, non-elderly, and elderly subgroups. The association between NO and NPC was significantly positively correlated in male, female, rural areas, and elderly subgroups. In conclusion, our study's findings demonstrated that exposure to airborne SO, NO, and PM can negatively impact the risk of incident NPC.
暴露于环境空气污染与患癌风险增加相关，但此前很少有研究关注环境空气污染与鼻咽癌（NPC）之间的关联。因此，我们的目标是研究杭州的环境空气污染暴露（包括二氧化硫（SO）、二氧化氮（NO）和可吸入颗粒物（PM））是否会对患癌风险产生影响。我们收集了2013年1月1日至2022年12月31日期间杭州的每日环境空气污染数据、气候以及NPC的每日发病率。我们应用基于泊松分布的广义相加模型（GAM）来研究环境空气污染对NPC发病风险的影响。还按年龄、性别、地区和季节在亚组中讨论了环境空气污染暴露对NPC的影响。研究期间共纳入3121例NPC发病病例。我们发现，SO、NO和PM浓度每增加1μg/m，NPC发病风险分别增加0.75%（95%CI：0.01 - 1.58）、0.36%（95%CI：0.03 - 0.69）和0.14%（95%CI：0.01 - 0.28）。即使在控制了其他环境空气污染物之后，这些污染物对NPC发病风险仍有显著影响。一个值得注意的肯定关联是，在男性、温暖季节、城市地区和老年亚组中，SO与NPC之间存在显著正相关。与SO相反，在女性、温暖季节、农村地区、非老年和老年亚组中，PM与NPC之间存在显著正相关。在男性、女性、农村地区和老年亚组中，NO与NPC之间的关联显著正相关。总之，我们的研究结果表明，暴露于空气中的SO、NO和PM会对NPC发病风险产生负面影响。
