Bachtiar Endang Winiati, Putri Atikah Cyntia, Bachtiar Boy Muchlis
Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, DKI Jakarta, 10430, Indonesia.
F1000Res. 2019 Oct 11;8:1744. doi: 10.12688/f1000research.20099.2. eCollection 2019.
Salivary nitric oxide plays an important role as an antibacterial agent in the oral cavity. Here, we analyze salivary nitric oxide, Simplified Oral Hygiene Index (OHI-S) scores and the salivary flow rate in smokers and non-smokers which has not been done previously. A cross sectional study included 25 smokers and 25 non-smokers. Their OHI-S results were categorized as "good," "medium," or "bad." Unstimulated saliva samples were collected, and their nitric oxide concentration was measured using the Griess method. The salivary flow rate in smokers was lower, at 0.30 ml/minute, compared to non-smokers who had a salivary flow rate of 0.33 ml/minute. This was statistically insignificant. There was a significant difference in the concentrations of nitric oxide between smokers and non-smokers (p < 0.05). Smokers had higher concentrations than non-smokers (185.4 µM Vs 114.60 µM). In addition, there was a moderate positive correlation (r = 0.305) between the concentration of salivary nitric oxide level and the OHI-S results. It was concluded that salivary nitric oxide concentration was higher in smokers, and the oral hygiene condition of smokers was poor.
唾液中的一氧化氮在口腔中作为一种抗菌剂发挥着重要作用。在此，我们分析了吸烟者和非吸烟者的唾液一氧化氮、简化口腔卫生指数（OHI-S）得分以及唾液流速，此前尚未有过此类研究。一项横断面研究纳入了25名吸烟者和25名非吸烟者。他们的OHI-S结果被分为“良好”“中等”或“较差”。收集未受刺激的唾液样本，并使用格里斯方法测量其一氧化氮浓度。吸烟者的唾液流速较低，为0.30毫升/分钟，而非吸烟者的唾液流速为0.33毫升/分钟。这在统计学上无显著差异。吸烟者和非吸烟者之间的一氧化氮浓度存在显著差异（p < 0.05）。吸烟者的浓度高于非吸烟者（185.4微摩尔/升对114.60微摩尔/升）。此外，唾液一氧化氮水平浓度与OHI-S结果之间存在中度正相关（r = 0.305）。研究得出结论，吸烟者的唾液一氧化氮浓度较高，且吸烟者的口腔卫生状况较差。
