Pateel Deepak Gowda Sadashivappa, Gunjal Shilpa, Fong Liew Fong, Hanapi Nur Sulwana Mohd
Department of Oral Pathology Oral Medicine, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Department of Dental Public Health, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Int J Dent. 2021 Feb 23;2021:1982083. doi: 10.1155/2021/1982083. eCollection 2021.
Saliva, as a complex biofluid, plays a pivotal role in maintaining oral health and tooth integrity. There has been inconsistent data available on the relationship between salivary parameters and oral health. This study aims to investigate the association between salivary statherin, acidic proline-rich proteins (aPRP), and calcium with oral hygiene status.
One hundred and eighty-eight healthy subjects aged between 18 and 50 years with varying oral hygiene status who gave consent to participate were included in this cross-sectional study. The subjects were recruited from primary oral health care of MAHSA University. Oral hygiene of all the participants was measured using Oral Hygiene Index-Simplified (OHI-S). Stimulated saliva collected using paraffin wax was analyzed for salivary statherin, aPRP, and calcium. The relationship between salivary statherin, aPRP, and calcium levels with OHI-S was assessed using Spearman's Rank correlation coefficient; the strength of relationship was assessed by multiple linear regression analysis.
The study found a weak positive correlation ( = 0.179, = 0.014) between salivary statherin and OHI-S; weak negative correlation ( = -0.187, = 0.010) between salivary aPRP and OHI-S; and moderate negative correlation between salivary statherin and salivary aPRP levels ( = -0.50, < 0.001) which were statistically significant.
Poor oral hygiene is associated with increased statherin and reduced aPRP levels in saliva. Thus, these salivary components may have a role in predicting oral hygiene status.
唾液作为一种复杂的生物流体，在维持口腔健康和牙齿完整性方面起着关键作用。关于唾液参数与口腔健康之间的关系，现有数据并不一致。本研究旨在调查唾液中富含脯氨酸的酸性蛋白（aPRP）、磷蛋白与钙和口腔卫生状况之间的关联。
本横断面研究纳入了188名年龄在18至50岁之间、口腔卫生状况各异且同意参与的健康受试者。这些受试者从马来西亚玛莎大学初级口腔保健中心招募。使用简化口腔卫生指数（OHI-S）测量所有参与者的口腔卫生状况。使用石蜡刺激采集的唾液，分析其中的磷蛋白、aPRP和钙。采用Spearman等级相关系数评估唾液磷蛋白、aPRP和钙水平与OHI-S之间的关系；通过多元线性回归分析评估关系强度。
研究发现唾液磷蛋白与OHI-S之间存在弱正相关（r = 0.179，P = 0.014）；唾液aPRP与OHI-S之间存在弱负相关（r = -0.187，P = 0.010）；唾液磷蛋白与唾液aPRP水平之间存在中度负相关（r = -0.50，P < 0.001），均具有统计学意义。
口腔卫生状况差与唾液中磷蛋白增加和aPRP水平降低有关。因此，这些唾液成分可能在预测口腔卫生状况方面发挥作用。
