Department of Epidemiology, Binzhou Medical University, Yantai, ShanDong, P.R. China.
Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, ShanDong, P.R. China.
Asia Pac J Clin Oncol. 2021 Apr;17(2):e3-e9. doi: 10.1111/ajco.13300. Epub 2020 Feb 7.
HOX transcript antisense intergenic RNA (HOTAIR) is considered a diagnostic biomarker for cancer; however, results of previous studies on HOTAIR are inconsistent. In this meta-analysis, we aimed to investigate the role of HOTAIR in cancer diagnosis. Medline, PubMed, Embase, Ovid, Web of Science and Cochrane databases were searched for relevant literature up to May 2019. Over all, we included 20 studies from 17 articles on the role of HOTAIR in cancer diagnosis (individual diagnosis) and 7 studies from 6 articles on the role of HOTAIR along with other biomarkers in cancer diagnosis (combinative diagnosis). The sensitivity and specificity of HOTAIR-mediated individual diagnosis of cancers were 0.80 (95% confidence interval [CI], 0.74-0.85) and 0.74 (95% CI, 0.66-0.81), respectively. The sensitivity and specificity of HOTAIR-mediated combinative diagnosis of cancer were 0.82 (95% CI, 0.77-0.87) and 0.86 (95% CI, 0.80-0.91), respectively. The areas under the receiver operating characteristic curve for individual and combinative diagnoses was 0.84 (95% CI, 0.81-0.87) and 0.91 (95% CI, 0.88-0.93), respectively, indicating that a combinative diagnosis has a relatively better diagnostic accuracy (z = -2.22, P = 0.01) than individual diagnosis. In conclusion, HOTAIR levels might be a promising biomarker in cancer diagnosis. In addition, using HOTAIR in combination with other biomarkers showed a relatively better diagnostic accuracy than HOTAIR alone.
HOX 转录反义基因间 RNA（HOTAIR）被认为是癌症的诊断生物标志物；然而，之前关于 HOTAIR 的研究结果并不一致。在这项荟萃分析中，我们旨在研究 HOTAIR 在癌症诊断中的作用。我们检索了 Medline、PubMed、Embase、Ovid、Web of Science 和 Cochrane 数据库，以获取截至 2019 年 5 月的相关文献。总共，我们纳入了 20 项关于 HOTAIR 在癌症诊断（个体诊断）中的作用的研究（来自 17 篇文章）和 7 项关于 HOTAIR 与其他生物标志物联合诊断癌症的研究（来自 6 篇文章）。HOTAIR 介导的癌症个体诊断的敏感性和特异性分别为 0.80（95%置信区间[CI]，0.74-0.85）和 0.74（95%CI，0.66-0.81）。HOTAIR 介导的癌症联合诊断的敏感性和特异性分别为 0.82（95%CI，0.77-0.87）和 0.86（95%CI，0.80-0.91）。个体和联合诊断的受试者工作特征曲线下面积分别为 0.84（95%CI，0.81-0.87）和 0.91（95%CI，0.88-0.93），这表明联合诊断的诊断准确性相对较高（z=-2.22，P=0.01）。总之，HOTAIR 水平可能是癌症诊断中一种有前途的生物标志物。此外，与单独使用 HOTAIR 相比，将 HOTAIR 与其他生物标志物联合使用显示出相对更好的诊断准确性。
