Fekadu Ginenus, Chelkeba Legese, Melaku Tsegaye, Tegene Elsah, Kebede Ayantu
Department of Pharmacy, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.
School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia.
Ann Med Surg (Lond). 2020 Mar 21;53:1-11. doi: 10.1016/j.amsu.2020.03.001. eCollection 2020 May.
Stroke is one of the most common medical emergencies and the leading cause of preventable death and long-term disability worldwide. A prospective cohort study was conducted at the stroke unit of Jimma university medical center for four consecutive months (from March 10 to July 10, 2017). Of the total 116 study patients, 60 (51.7%) had an ischemic stroke. At 30-day follow-up, 81 (69.8%) patients were alive, 34 (29.3%) were died, and one patient (0.9%) was lost to follow-up. Elevated alanine aminotransferase (ALT) level (), diagnosis of stroke clinically alone ( brain edema ( and National Institute of Health Stroke Scale (NIHSS) ≥ 13 during hospital arrival were the independent predictors of 30-day mortality. At 60-day follow-up, 68 (58.6%) patients were alive, 46 (39.7%) were died, and 2 (1.7%) were lost to follow-up. Discharge against medical advice ( and severe modified Rankin score/mRS (4-5) at discharge ( were the independent predictors of 60-day mortality. The median (IQR) length of survival after hospital admission for patients died within 30 and 60 days were 4.65 (2.34-11.80) and 9.3 (3.93-33) days, respectively. Stroke significantly affects the morbidity and mortality in Ethiopia. There is a need to provide better care and future planning for stroke patients as an emergency diagnosis and treatment to minimize mortality and disability.
中风是最常见的医疗急症之一，也是全球可预防死亡和长期残疾的主要原因。在吉姆马大学医学中心的中风单元进行了一项为期四个月的前瞻性队列研究（从2017年3月10日至7月10日）。在总共116名研究患者中，60名（51.7%）患有缺血性中风。在30天随访时，81名（69.8%）患者存活，34名（29.3%）死亡，1名患者（0.9%）失访。丙氨酸转氨酶（ALT）水平升高、仅临床诊断为中风、脑水肿以及入院时美国国立卫生研究院卒中量表（NIHSS）≥13是30天死亡率的独立预测因素。在60天随访时，68名（58.6%）患者存活，46名（39.7%）死亡，2名（1.7%）失访。违反医嘱出院以及出院时严重改良Rankin评分/mRS（4 - 5）是60天死亡率的独立预测因素。在30天和60天内死亡的患者入院后存活时间的中位数（四分位间距）分别为4.65（2.34 - 11.80）天和9.3（3.93 - 33）天。中风对埃塞俄比亚的发病率和死亡率有显著影响。有必要为中风患者提供更好的护理和未来规划，作为紧急诊断和治疗，以尽量减少死亡率和残疾率。
