State Key Laboratory of Food Science and Technology, School of Food Science and Technology, National Engineering Research Center for Functional Food, School of Food Science Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.
School of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, Zhejiang, 310058, People's Republic of China.
Biosens Bioelectron. 2020 May 15;156:112085. doi: 10.1016/j.bios.2020.112085. Epub 2020 Feb 8.
Pathogenic bacterial infections are a significant threat to human safety and health. Recent researches on the application of nanoparticles as imaging, detecting agents have evidenced their huge potential for infectious disease management. Among these nanoparticles, carbon dots (CDs) have attracted much attention as a new and innovative nanoparticle owing to their unique optical and physicochemical properties as well as their higher biosafety. Thus, CDs are becoming superior candidates for imaging and detection of pathogenic bacteria. This review provides an overview of research advances and the mechanisms in the imaging and detection pathogenic bacteria such as "switch on" sensor, "on-off" sensor, förster resonance energy transfer (FRET), etc. Further, our discussion extends to exploring the antibacterial effects of CDs, which is considered to be a potentially promising antibacterial agent. This review would provide the basis and the direction for the further commercial applications of CDs in imaging, detecting and eliminating pathogenic bacteria. The challenges associated with CDs in monitoring of pathogenic bacteria and future directions in this field are also presented.
致病细菌感染对人类安全和健康构成重大威胁。最近关于纳米粒子作为成像、检测试剂的应用研究证明了它们在传染病管理方面的巨大潜力。在这些纳米粒子中，由于其独特的光学和物理化学性质以及更高的生物安全性，碳点 (CDs) 作为一种新型创新纳米粒子引起了广泛关注。因此，CDs 成为成像和检测致病菌的理想候选物。本综述概述了成像和检测致病菌的研究进展和机制，如“开启”传感器、“关闭”传感器、荧光共振能量转移 (FRET) 等。此外，我们的讨论还扩展到了对 CDs 的抗菌作用的探索，这被认为是一种有前途的潜在抗菌剂。本综述将为 CDs 在成像、检测和消除致病菌方面的进一步商业应用提供基础和方向。还介绍了与 CDs 监测致病菌相关的挑战以及该领域的未来发展方向。
