Liver Transplantation Center, The Fifth Medical Center of Chinese PLA General Hospital, 100 West 4th Ring Middle Road, Beijing, 100039, China.
Humanity and Health Medical Group, Humanity and Health Clinical Trial Center, Unit 2101, 21F, No. 9 Queen's Road Central, Hong Kong, SAR, China.
Hepatol Int. 2020 Jul;14(4):432-436. doi: 10.1007/s12072-020-10043-z. Epub 2020 Apr 10.
Annually, around 850 liver transplantation is performed in Beijing, China. Recently, the new coronavirus pneumonia (COVID-19) caused by 2019 novel coronavirus (2019-nCoV) has affected nearly 200 countries worldwide. 2019-nCov can cause severe lung disease, multiple-organ damage, and significant mortalities. Liver transplant recipients, because of long-term oral immunosuppressant effects, may be more susceptible to 2019-nCoV infection and have a worse prognosis than the general population. It is urgent to set up guidelines for the prevention, diagnosis, and treatment of COVID-19 in liver transplant recipients. In this article, we reviewed the clinical aspects of 2019-nCoV infection, characteristics of liver transplant recipients, immunosuppressant usage, and potential drug interactions to provide recommendations to clinical staff managing liver transplant recipients during the COVID-19 epidemic.
每年,中国北京大约进行 850 例肝移植。最近,由 2019 年新型冠状病毒(2019-nCoV)引起的新型冠状病毒肺炎(COVID-19)已在全球近 200 个国家蔓延。2019-nCoV 可引起严重的肺部疾病、多器官损伤,并导致较高的死亡率。由于长期口服免疫抑制剂的影响,肝移植受者可能更容易感染 2019-nCoV,且预后较普通人群更差。因此,迫切需要制定肝移植受者预防、诊断和治疗 COVID-19 的指南。在本文中,我们复习了 2019-nCoV 感染的临床特点、肝移植受者的特征、免疫抑制剂的应用以及潜在的药物相互作用,以期为临床医护人员在 COVID-19 流行期间管理肝移植受者提供建议。