Kremers Inge, Hohberger Bettina, Bergua Antonio
Department of Ophthalmology, University of Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Schwabachanlage 6, 91054, Erlangen, Germany.
Graefes Arch Clin Exp Ophthalmol. 2020 Jul;258(7):1515-1522. doi: 10.1007/s00417-020-04673-0. Epub 2020 Apr 11.
Current therapies of Meibomian gland dysfunction (MGD) include thermal eyelid warming. It was the aim of the study to investigate the temperature run after eyelid warming using 3 different techniques (hot compresses, Blephasteam® (Thea Pharma GmbH, France), and having a sauna) in patients with MGD compared with normal subjects by infrared thermography.
A prospective case-control study was done. Temperature profiles of the eyelids were investigated in 93 subjects (49 normals, 44 MGD patients) after warming of the eyelids by 3 methods: hot compresses, Blephasteam®, and having a sauna. Temperature runs of the eyelids were measured with an infrared thermal imaging camera (VarioCAM® HD research 675/30 mm, InfraTec GmbH) at baseline and after eyelid warming for 10 min. Statistical analysis were done by Wilcoxon test or t tests for unpaired samples.
The initial eyelid temperature was significantly increased after the use of Blephasteam® compared with hot compresses in MGD and normal patients (p < 0.001). Having a sauna showed a similar warming effect of the eyelids than Blephasteam in normals and MGD patients (p > 0.05). Additionally, the warming effect of the eyelids after having a sauna was significantly longer than after the use of Blephasteam® in MGD (p = 0.016) and normal patients (p = 0.01).
Eyelid temperature after having a sauna was similar to commonly used warming devices; yet, the duration of the eyelid warming effect was longer. Thus, having a sauna might be an alternative option for warming of the eyelids.
睑板腺功能障碍（MGD）的当前治疗方法包括眼睑温热疗法。本研究旨在通过红外热成像技术，调查MGD患者与正常受试者使用3种不同技术（热敷、Blephasteam®（法国Thea Pharma GmbH公司）和蒸桑拿）进行眼睑温热后的温度变化情况。
开展一项前瞻性病例对照研究。通过3种方法（热敷、Blephasteam®和蒸桑拿）对93名受试者（49名正常人，44名MGD患者）的眼睑进行温热后，研究其眼睑温度变化情况。在基线状态以及眼睑温热10分钟后，使用红外热成像相机（VarioCAM® HD research 675/30 mm，InfraTec GmbH公司）测量眼睑的温度变化。采用Wilcoxon检验或非配对样本t检验进行统计分析。
与热敷相比，MGD患者和正常患者使用Blephasteam®后初始眼睑温度显著升高（p < 0.001）。在正常人和MGD患者中，蒸桑拿对眼睑的温热效果与Blephasteam相似（p > 0.05）。此外，在MGD患者（p = 0.016）和正常患者（p = 0.01）中，蒸桑拿后眼睑的温热效果持续时间显著长于使用Blephasteam®后。
蒸桑拿后的眼睑温度与常用的温热设备相似；然而，眼睑温热效果的持续时间更长。因此，蒸桑拿可能是一种眼睑温热的替代选择。
