Dipartimento di Biologia e Biotecnologie, Università degli Studi di Pavia, via Ferrata 1, 27100, Pavia, Italy.
Reparti di Riabilitazione Geriatrica e di Mantenimento, Istituto Geriatrico P. Redaelli, via Leopardi 3 Vimodrone, 20090, Milano, Italy.
Aging Clin Exp Res. 2021 Feb;33(2):463-467. doi: 10.1007/s40520-020-01526-y. Epub 2020 Apr 11.
The purposes of this retrospective study were to document the prevalence of serum C-reactive protein (CRP), a biomarker of inflammation, and its potential predictive value for Rehabilitation outcomes in post-acute elderly inpatients. The medical records of 304 elderly subjects admitted to our Rehabilitation Institute for any disease following an acute event were examined. High levels of CRP (> 0.5 mg/dl) were present in 100% of the subjects, and the value > 1.5 mg/dl (n = 86) predicted unfavourable outcomes (n = 28; 32.5% of the patients: death or transfer to other institutions). Among the patients with favourable outcomes (discharge home n = 255), 62.7% still exhibited severe disabilities. Pressure ulcers and low functional status also predicted unfavourable outcomes. The study highlights the need for future investigations into the possible reduction of CRP levels, after an intensive nutritional approach and combined physical interventions.
本回顾性研究旨在记录炎症生物标志物血清 C 反应蛋白（CRP）在急性事件后入住我院康复科的老年住院患者中的流行程度及其对康复结局的潜在预测价值。对我院康复科收治的 304 名因任何疾病而入住的老年患者的病历进行了检查。所有患者 CRP 水平均升高（>0.5mg/dl），CRP 值>1.5mg/dl（n=86）预示不良结局（n=28，占患者的 32.5%：死亡或转至其他机构）。在结局良好的患者（n=255，出院回家）中，62.7%仍存在严重残疾。压疮和功能状态低下也预示着不良结局。该研究强调了未来需要进一步研究在强化营养和联合物理干预后 CRP 水平可能降低的问题。
