Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China.
Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, China.
J Biomater Appl. 2020 Jul;35(1):28-38. doi: 10.1177/0885328220916968. Epub 2020 Apr 11.
Multifunctional nanocarriers have been widely accepted and utilized for biomedical applications, because of their structural regularity, convenient post-modification and controllable structure and morphology. Herein, we reported polydopamine-doped virus-like mesoporous silica coated reduced graphene oxide nanosheets (rGO@PVMSNs) nanocomposites by a facile oil-water biphase stratification method. The synthesized rGO@PVMSNs nanocomposites performed excellent biocompatibility and photothermal performance. They could be employed as photoacoustic imaging contrast in vivo. Furthermore, the rGO@PVMSNs nanocarriers were used for loading the antitumor drug doxorubicin (DOX), the rGO@PVMSNs@DOX nanocomposites were also demonstrated to be with high inhibition of HepG2 cancer cells, especially with the help of near-infrared irradiation, which were more efficient than single chemotherapy or photothermal therapy. The rGO@PVMSNs@DOX nanocomposites of this work could be used as photoacoustic imaging and chemo-photothermal synergetic therapy agents, which show a new perspective for clinical tumor diagnosis and therapy.
多功能纳米载体因其结构规则、方便的后修饰以及可控的结构和形态，已被广泛接受和应用于生物医学领域。在此，我们通过简便的油-水两相分层法报道了聚多巴胺掺杂的病毒样介孔氧化硅包覆还原氧化石墨烯纳米片（rGO@PVMSNs）纳米复合材料。所合成的 rGO@PVMSNs 纳米复合材料表现出优异的生物相容性和光热性能。它们可作为体内光声成像造影剂。此外，rGO@PVMSNs 纳米载体被用于负载抗肿瘤药物阿霉素（DOX），rGO@PVMSNs@DOX 纳米复合材料也表现出对 HepG2 癌细胞的高抑制作用，特别是在近红外辐射的帮助下，其效果优于单一化疗或光热治疗。这项工作中的 rGO@PVMSNs@DOX 纳米复合材料可用作光声成像和化疗-光热协同治疗剂，为临床肿瘤诊断和治疗提供了新的视角。
