Biocomposite Fabrication Lab, Department of Metallurgical and Materials Engineering, DIAT (DU), Ministry of Defence, Girinagar, Pune-411025, India.
Biomater Sci. 2018 Jun 25;6(7):1691-1711. doi: 10.1039/c8bm00312b.
Cyanoacrylate adhesives and their homologues have elicited interest over the past few decades owing to their applications in the biomedical sector, extending from tissue adhesives to scaffolds to implants to dental material and adhesives, because of their inherent biocompatibility and ability to polymerize solely with moisture, thanks to which they adhere to any substrate containing moisture such as the skin. The ability to tailor formulations of alkyl cyanoacrylate to form derivative compounds to meet application requirements along with their biodegradability in conjunction with their inherent biocompatibility make them highly sought after candidates in the biomedical sector. There has been extensive exploration of cyanoacrylate adhesives and their homologue systems in biomedical applications, but no consolidated literature of the vast data is available. The ability of cyanoacrylate adhesives to cure at low temperatures and without the need for any hardener, which is attributed to the high-strength bonding interaction between two non-amalgamating substrates, with their ease of dispersion and self-curing, avoids the curtailing of the effective utilization of such adhesives in biomedical engineering applications as bio glues for amalgamating tissues, implants, scaffolds etc. This article consolidates copious work on cyanoacrylate adhesives and their derived systems which are functional in versatile biomedical engineering applications such as bio glues, dental material and adhesives and other potential applications.
氰基丙烯酸酯粘合剂及其同系物在过去几十年中引起了人们的兴趣，因为它们在生物医学领域的应用广泛，从组织粘合剂到支架到植入物到牙科材料和粘合剂，这要归功于它们固有的生物相容性和仅能与水分聚合的能力，这使得它们可以附着在任何含有水分的基质上，如皮肤。可以通过调整烷基氰基丙烯酸酯的配方来形成衍生化合物，以满足应用要求，同时具有生物降解性和固有生物相容性，这使得它们成为生物医学领域的热门候选材料。人们已经对氰基丙烯酸酯粘合剂及其同系物系统在生物医学应用中的进行了广泛的探索，但由于数据庞大，尚未有综合文献可供参考。氰基丙烯酸酯粘合剂能够在低温下固化，并且不需要任何硬化剂，这归因于两个非合金化基材之间高强度的键合相互作用，以及其易于分散和自固化的特性，避免了在生物医学工程应用中，如用于组织、植入物、支架等的生物胶，限制了这些粘合剂的有效利用。本文综合了大量关于氰基丙烯酸酯粘合剂及其衍生系统的工作，这些系统在生物医学工程应用中具有多功能性，如生物胶、牙科材料和粘合剂以及其他潜在应用。
