Lamers Susanna L, Rose Rebecca, Cross Sissy, Rodriguez Christopher W, Redd Andrew D, Quinn Thomas C, Serwadda David, Kagaayi Joseph, Kigozi Godfrey, Galiwango Ronald, Gray Ronald H, Grabowski M Kate, Laeyendecker Oliver
BioInfoExperts LLC, Thibodaux, Louisiana, USA.
Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH, Baltimore, Maryland, USA.
AIDS Res Hum Retroviruses. 2020 Jun;36(6):522-526. doi: 10.1089/AID.2020.0062.
The Rakai Community Cohort Study in south central Uganda has surveyed people aged 15-49 since 1994. Antiretroviral therapy (ART) was introduced in 2004. HIV p24 and gp41 subtype distribution and viral diversity were studied from blood samples collected at three surveys in 1994-1995, 2002-2003, and 2008-2009, which were compared with a new survey round from 2011 to 2012. These included 1364 HIV+ individuals. For both p24 and gp41 domains, the genetic diversity within subtypes A and D was significantly increasing in the pre-ART era and decreased between the last two survey rounds in the ART era ( < .01). This study suggests that despite ongoing mixing of viral subtypes, an association with the introduction of ART to a reduction of intra-subtype viral genomic diversity may be occurring, which can be explored in ongoing studies.
乌干达中南部的拉凯社区队列研究自1994年起对15至49岁的人群进行调查。抗逆转录病毒疗法（ART）于2004年引入。对1994 - 1995年、2002 - 2003年和2008 - 2009年三次调查采集的血样进行了HIV p24和gp41亚型分布及病毒多样性研究，并与2011年至2012年的新一轮调查进行比较。这些血样来自1364名HIV阳性个体。对于p24和gp41结构域，在抗逆转录病毒疗法时代之前，A和D亚型内的基因多样性显著增加，而在抗逆转录病毒疗法时代的最后两轮调查之间有所下降（<0.01）。这项研究表明，尽管病毒亚型持续混合，但可能存在与引入抗逆转录病毒疗法导致亚型内病毒基因组多样性降低之间的关联，这一点可在正在进行的研究中进一步探讨。
