Barnes P, Waterworth P M
Br Med J. 1977 Apr 16;1(6067):991-3. doi: 10.1136/bmj.1.6067.991.
A large empyema infected with a penicillin-sensitive haemolytic group B streptococcus failed to respond to high doses of penicillin. After two weeks' treatment the pus aspirated was found not only to contain no penicillin, but also to inactivate penicillin added to it. We believe that the inactivating agent is an enzyme that may destroy various penicillins and cephalosporins but has no effect on other common antibiotics. When treatment was changed to doxycycline the patient made a rapid recovery.
一例由对青霉素敏感的B组溶血性链球菌感染引起的大量脓胸，对大剂量青霉素治疗无反应。经过两周治疗后发现，抽出的脓液不仅不含青霉素，而且还会使加入其中的青霉素失活。我们认为这种失活剂是一种酶，它可能会破坏各种青霉素和头孢菌素，但对其他常用抗生素没有影响。当改用强力霉素治疗后，患者迅速康复。
