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Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment?

作者信息

Patrì Angela, Fabbrocini Gabriella

机构信息

Section of Dermatology and Venereology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

Section of Dermatology and Venereology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

出版信息

J Am Acad Dermatol. 2020 Jun;82(6):e221. doi: 10.1016/j.jaad.2020.04.017. Epub 2020 Apr 10.

DOI:10.1016/j.jaad.2020.04.017
PMID:32283237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7146719/
Abstract
摘要

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The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.美国食品药品监督管理局批准的药物伊维菌素可抑制 SARS-CoV-2 的体外复制。
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2
COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression.COVID-19:建议检查羟氯喹预防感染和进展的效果。
J Antimicrob Chemother. 2020 Jul 1;75(7):1667-1670. doi: 10.1093/jac/dkaa114.
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In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).羟氯喹治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2)的体外抗病毒活性和优化剂量设计预测。
Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237.
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Ivermectin inhibits DNA polymerase UL42 of pseudorabies virus entrance into the nucleus and proliferation of the virus in vitro and vivo.伊维菌素抑制伪狂犬病病毒进入细胞核的 DNA 聚合酶 UL42 和病毒在体外和体内的增殖。
Antiviral Res. 2018 Nov;159:55-62. doi: 10.1016/j.antiviral.2018.09.010. Epub 2018 Sep 26.
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Treatment of Human Scabies with Oral Ivermectin. Eczematous Eruptions as a New Non-Reported Adverse Event.口服伊维菌素治疗人类疥疮。湿疹样皮疹作为一种新的未报告的不良事件。
Actas Dermosifiliogr. 2017 Sep;108(7):643-649. doi: 10.1016/j.ad.2017.02.011. Epub 2017 Apr 3.