类器官在乳腺癌研究中的应用进展。
Progress in the application of organoids to breast cancer research.
机构信息
Department of Breast Surgery, Peking University Shenzhen Hospital, Shenzhen, China.
Department of Breast Surgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
出版信息
J Cell Mol Med. 2020 May;24(10):5420-5427. doi: 10.1111/jcmm.15216. Epub 2020 Apr 13.
Abstract
Breast cancer is the most common cancer diagnosed in women. Breast cancer research is currently based mainly on animal models and traditional cell culture. However, the inherent species gap between humans and animals, as well as differences in organization between organs and cells, limits research advances. The breast cancer organoid can reproduce many of the key features of human breast cancer, thereby providing a new platform for investigating the mechanisms underlying the development, progression, metastasis and drug resistance of breast cancer. The application of organoid technology can also promote drug discovery and the design of individualized treatment strategies. Here, we discuss the latest advances in the use of organoid technology for breast cancer research.
摘要
乳腺癌是女性最常见的癌症。乳腺癌研究目前主要基于动物模型和传统细胞培养。然而，人类和动物之间固有的种间差异以及器官和细胞之间的组织差异限制了研究进展。乳腺癌类器官可以再现许多人类乳腺癌的关键特征，从而为研究乳腺癌的发生、发展、转移和耐药机制提供了新的平台。类器官技术的应用也可以促进药物发现和个体化治疗策略的设计。在这里，我们讨论了类器官技术在乳腺癌研究中的最新进展。
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