Molina Gustavo A, Elizalde-Mata Alberto, Hernández-Martínez Ángel R, Fonseca Gerardo, Cruz Soto Martha, Rodríguez-Morales Ángel Luis, Estevez Miriam
Posgrado en Ciencia e Ingeniería de Materiales, Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3000, Querétaro 76230, Mexico.
Centro de Física Aplicada y Tecnología Avanzada (CFATA), Universidad Nacional Autónoma de México (UNAM), Blvd. Juriquilla 3000, Querétaro 76230, Mexico.
Polymers (Basel). 2020 Apr 9;12(4):865. doi: 10.3390/polym12040865.
In this study, new polyurethanes (PUs) were prepared by using inulin and polycaprolactone as polyols. Their structure and morphology were determined by Fourier transform infrared spectroscopy (FTIR), Raman dispersive spectroscopy, Nuclear magnetic resonance spectroscopy (H NMR and C NMR), and scanning electron microscopy (SEM), whereas their mechanical properties were evaluated by a universal testing machine. Additionally, their water uptake, swelling behavior, and degradation were evaluated to be used as drug delivery carriers. Therefore, an anti-cancer drug was loaded to these PUs with 25% of loading efficiency and its release behavior was studied using different theoretical models to unveil its mechanism. Finally, the ability of the new PUs to be used as a clip marker in breast biopsy was evaluated. The results clearly demonstrate that these PUs are safe and can be used as intelligent drug release matrices for targeted drug delivery and exhibits positive results to be used for clip marker and in general for breast cancer applications.
在本研究中，以菊粉和聚己内酯为多元醇制备了新型聚氨酯（PU）。通过傅里叶变换红外光谱（FTIR）、拉曼色散光谱、核磁共振光谱（¹H NMR和¹³C NMR）以及扫描电子显微镜（SEM）确定了它们的结构和形态，而通过万能试验机评估了它们的机械性能。此外，还评估了它们的吸水性、溶胀行为和降解情况，以用作药物递送载体。因此，将一种抗癌药物以25%的负载效率负载到这些聚氨酯上，并使用不同的理论模型研究其释放行为以揭示其机制。最后，评估了新型聚氨酯在乳腺活检中用作夹子标记物的能力。结果清楚地表明，这些聚氨酯是安全的，可作为用于靶向药物递送的智能药物释放基质，并且在用作夹子标记物以及一般用于乳腺癌应用方面都显示出积极的结果。
