Singh Karanvir, Sikka Pooja, Suri Vanita, Prasad Rishikesh, Khullar Madhu, Vijayvergiya Rajesh
Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Obstet Med. 2020 Mar;13(1):25-29. doi: 10.1177/1753495X18819351. Epub 2019 Feb 2.
Plasma brain natriuretic peptide levels were prospectively studied in pregnant women with heart disease.
Fifty pregnant women with heart disease and 25 controls were evaluated at 24 weeks or under, 30-32 weeks, 34 weeks or more of gestation, and 6 weeks postpartum. Adverse maternal cardiac events were hospitalization for worsening heart failure, stroke, and death.
Thirty-eight (76%) women had rheumatic heart disease. Plasma brain natriuretic peptide levels were (in cases and controls) 118.3 ± 46.5 pg/ml and 66.3 ± 15.9 pg/ml (at 24 weeks or under), 124.8 ± 30.4 pg/ml and 68.4 ± 16.5 pg/ml (30-32 weeks), 135.8 ± 34.9 pg/ml and 68.6 ± 15.6 pg/ml (34 weeks or more), and 110.1 ± 21.9 pg/ml and 65.0 ± 16.1 pg/ml (6 weeks postpartum) (p = .0001). Eighteen women had adverse events. Of these, only 1 had a level less than 100 pg/ml, 12 were between 100 and 200 pg/ml, and 5 more than 200 pg/ml.
Plasma brain natriuretic peptide levels were higher in women with heart disease at all periods of gestation as well as six weeks postpartum. No woman with a plasma brain natriuretic peptide levels of 98 pg/ml or less had an adverse event.
对患有心脏病的孕妇进行了血浆脑钠肽水平的前瞻性研究。
对50例患有心脏病的孕妇和25例对照者在妊娠24周及以内、30 - 32周、34周及以上以及产后6周进行评估。孕产妇不良心脏事件包括因心力衰竭加重、中风和死亡而住院。
38名（76%）女性患有风湿性心脏病。（病例组和对照组的）血浆脑钠肽水平在妊娠24周及以内时分别为118.3±46.5 pg/ml和66.3±15.9 pg/ml，30 - 32周时分别为124.8±30.4 pg/ml和68.4±16.5 pg/ml，34周及以上时分别为135.8±34.9 pg/ml和68.6±15.6 pg/ml，产后6周时分别为110.1±21.9 pg/ml和65.0±16.1 pg/ml（p = 0.0001）。18名女性发生了不良事件。其中，只有1名女性的血浆脑钠肽水平低于100 pg/ml，12名在100至200 pg/ml之间，5名高于200 pg/ml。
患有心脏病的女性在妊娠各阶段以及产后6周时血浆脑钠肽水平均较高。血浆脑钠肽水平为98 pg/ml或更低的女性均未发生不良事件。
