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破骨细胞衍生的外泌体在磁纳米颗粒渗透的羟磷灰石支架调节骨质疏松模型中成骨细胞增殖中的重要作用。

The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model.

机构信息

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan 610064, P.R. China.

出版信息

Nanoscale. 2020 Apr 30;12(16):8720-8726. doi: 10.1039/d0nr00867b.

DOI:10.1039/d0nr00867b
PMID:32285072
Abstract

Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.

摘要

磁性羟磷灰石（MHA）支架通过改变破骨细胞衍生的外体货物和降低破骨细胞摄取外体的效率，促进骨质疏松模型中的成骨细胞增殖。值得注意的是，与 MHA 刺激相比，某些蛋白质（包括泛素、ATP 和活性氧）在破骨细胞衍生的外体货物中减少，而 Rho 激酶增加。

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