Zhao Caiyan, Chen Jingxiao, Zhong Ruibo, Chen Dean Shuailin, Shi Jinjun, Song Jibin
MOE Key Laboratory for Analytical Science of Food Safety and Biology Institution, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.
Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA.
Angew Chem Int Ed Engl. 2021 Apr 26;60(18):9804-9827. doi: 10.1002/anie.201915833. Epub 2020 Oct 29.
With the increasing recognition of the diverse roles and significance of oxidative species in the pathogenesis of many diseases, a tremendous amount of work on the development of oxidative-species-responsive materials has been conducted for 1) detecting oxygen metabolites or diagnosis of oxidative-stress-relevant diseases, 2) reducing oxidative stress in the disease sites, and/or 3) delivering therapeutic and diagnostic agents. In this review, we first discuss the distinct features and biological functions of each oxidative species. Then the selectivity and sensitivity of chemical linkers/groups to specific oxidative species and the underlying chemistry of their particular interactions are systematically elucidated. Their potential biomedical applications are also highlighted. We expect that this comprehensive review will provide more insights for the design and development of oxidative-species-selective materials for more effective diagnostic and therapeutic applications.
随着人们越来越认识到氧化物种在多种疾病发病机制中的多样作用和重要性，针对以下几个方面开展了大量关于开发氧化物种响应材料的工作：1）检测氧代谢产物或诊断与氧化应激相关的疾病；2）减轻疾病部位的氧化应激；和/或3）递送治疗和诊断药物。在本综述中，我们首先讨论每种氧化物种的独特特征和生物学功能。然后系统地阐明化学连接体/基团对特定氧化物种的选择性和敏感性及其特定相互作用的潜在化学原理。还强调了它们潜在的生物医学应用。我们期望这一全面综述能为设计和开发用于更有效诊断和治疗应用的氧化物种选择性材料提供更多见解。
