Rady Hanaa I, Kholy Amani El
Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Gaz Egypt Paediatr Assoc. 2018 Jun;66(2):35-38. doi: 10.1016/j.epag.2018.05.001. Epub 2018 May 8.
Recurrent wheezing is one of the leading causes of chronic illness in childhood. We aimed to evaluate the prevalence of Human Rhinovirus (HRV) infection in the acute attack of wheezy chest which began after a respiratory illness.
The study was conducted on 200 children aged 2 months to 5 years presenting to the emergency department with an acute wheezy episode either for the first time or recurrent wheeze defined as >2 reports of wheezing in the first 3 years of life. All subjects were subjected to a complete history and clinical examination. Chest X-ray was done to all subjects. Nasopharyngeal and oropharyngeal swabs were obtained from all subjects and the presence of HRV was determined by PCR examination.
By PCR method, 163 patients (81.5%) were positive for viral infection. Due to viral co-infection, 49.5% (99 cases) were +ve for Respiratory Syncytial virus followed by HRV 43.5% (87 cases).
HRV was the second common viral infection in children with wheezes. Its prevalence was more in winter with higher incidence of recurrence. Compared to the other respiratory viruses, it had the higher mortality 43.7%.
反复喘息是儿童慢性疾病的主要病因之一。我们旨在评估呼吸道疾病后开始的喘息性胸部急性发作中人类鼻病毒（HRV）感染的患病率。
该研究针对200名年龄在2个月至5岁之间首次出现急性喘息发作或反复喘息（定义为在生命的前3年中有>2次喘息报告）的儿童进行，这些儿童前往急诊科就诊。所有受试者均接受了完整的病史和临床检查。对所有受试者进行了胸部X光检查。从所有受试者中采集鼻咽和口咽拭子，并通过PCR检测确定是否存在HRV。
通过PCR方法，163例患者（81.5%）病毒感染呈阳性。由于病毒合并感染，49.5%（99例）呼吸道合胞病毒呈阳性，其次是HRV 43.5%（87例）。
HRV是喘息儿童中第二常见的病毒感染。其患病率在冬季更高，复发率也更高。与其他呼吸道病毒相比，其死亡率更高，为43.7%。
