Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Egypt.
Department of Dermatology, STD's and Andrology, Faculty of Medicine, Minia University, Al Minya, Egypt.
Int J Biol Macromol. 2020 Aug 1;156:262-270. doi: 10.1016/j.ijbiomac.2020.04.040. Epub 2020 Apr 11.
Despite the popularity of chitosan as a biodegradable polymer used in a variety of applications, clinical trials involving chitosan or its nanoparticles are still scarce. Moreover, the use of nutraceuticals as a replacement to conventional chemical treatments has become currently popular, and if combined with nanotechnology, nutraceuticals can achieve a comparable or even better therapeutic outcome. In the current work, chitosan nanoparticles loading the nutraceutical nicotinamide were optimized, characterized, and clinically tested on patients suffering from acne vulgaris. The topical merits of chitosan nanoparticles were proven, in which they exhibited strong skin adhesion ex vivo and high nicotinamide deposition in the different skin layers (stratum corneum, epidermis and dermis) amounting to a total of 68%. When clinically tested on patients, nicotinamide nanoparticles displayed 73% reduction in the inflammatory acne lesions compared to untreated areas, hence proving that chitosan nanoparticles can be a clinically sounding option for treatment of skin diseases.
尽管壳聚糖作为一种可生物降解的聚合物在各种应用中广受欢迎，但涉及壳聚糖或其纳米粒子的临床试验仍然很少。此外，将营养保健品用作传统化学治疗的替代品目前已经变得很流行，如果将其与纳米技术结合使用，营养保健品可以达到类似甚至更好的治疗效果。在当前的工作中，优化了负载营养保健品烟酰胺的壳聚糖纳米粒子，并对患有寻常痤疮的患者进行了临床测试。壳聚糖纳米粒子具有很强的皮肤附着性，在不同的皮肤层（角质层、表皮和真皮）中烟酰胺的沉积量高达 68%，这证明了壳聚糖纳米粒子的局部优点。在对患者进行临床测试时，与未治疗区域相比，烟酰胺纳米粒子使炎症性痤疮病变减少了 73%，这证明壳聚糖纳米粒子可以成为治疗皮肤病的一种合理的临床选择。
