Department of Psychiatry, University of Iowa, Iowa City, IA, United States.
Department of Neurology, University of Iowa, Iowa City, IA, United States.
Brain Stimul. 2020 May-Jun;13(3):578-581. doi: 10.1016/j.brs.2020.01.010. Epub 2020 Jan 14.
No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule.
Evaluate the anatomical reliability of technician-identified DLPFC targets and obtain consensus average brain and scalp MNI152 coordinates.
Three trained TMS technicians performed repeated targeting using both the Beam F3 method and 5.5 cm rule in ten healthy subjects (n = 162). Average target locations were plotted on 7T structural MRIs to compare inter- and intra-rater reliability, respectively.
(1) Beam F3 inter- and intra-rater reliability was superior to 5.5 cm targeting (p = 0.0005 and 0.0035). (2) The average Beam F3 location was 2.6±1.0 cm anterolateral to the 5.5 cm method.
Beam F3 targeting demonstrates greater precision and reliability than the 5.5 cm method and identifies a different anatomical target.
在临床经颅磁刺激（TMS）领域，对于治疗抑郁症的左背外侧前额叶皮层（DLPFC）的最佳靶向方法尚无共识。两种常见的靶向方法是 Beam F3 方法和 5.5 厘米规则。
评估技术人员确定的 DLPFC 目标的解剖学可靠性，并获得共识的平均脑和头皮 MNI152 坐标。
三名经过培训的 TMS 技术人员在十名健康受试者中（n=162）分别使用 Beam F3 方法和 5.5 厘米规则进行了重复靶向。将平均目标位置绘制在 7T 结构 MRI 上，以分别比较组内和组间的可靠性。
（1）Beam F3 的组内和组间可靠性优于 5.5 厘米靶向（p=0.0005 和 0.0035）。（2）Beam F3 的平均位置比 5.5 厘米方法在前外侧方向上提前了 2.6±1.0 厘米。
Beam F3 靶向比 5.5 厘米方法具有更高的精度和可靠性，并且确定了不同的解剖学目标。
