Lazzari Massimo, Torneiro Mercedes
Departamento de Química Física, Facultade de Química and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Departamento de Química Orgánica, Facultade de Química, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Polymers (Basel). 2020 Apr 10;12(4):869. doi: 10.3390/polym12040869.
In this systematic review, a total of 45,143 publications on block copolymers, issued between 1952 and 2019, are analyzed in terms of number, source, language, institution, country, keywords, and block copolymer type, to find out their evolution and predict research trends. The number of publications devoted to block copolymers has been growing for over six decades, maintaining a consistent level throughout the last few years. In their majority, documents came out of the United States, although more recently, Chinese institutions are those displaying the largest production. Keywords analysis indicated that one-third of the publications concerned synthesis, around 20% explored self-assembly and morphological aspects, and another 20% referred to block copolymer applications in solution. In particular, 2019 confirmed the expansion of studies related to drug delivery, and in minor extent, to a deeper view of self-assembling. Styrene-butadiene-styrene block copolymer was the most popular in studies covering both basic and industrially oriented aspects. Other highly investigated copolymers are PEO--PPO--PEO (Pluronic©) and amphiphilic block copolymers based on polycaprolactone or poly(lactic acid), which owed their success to their potential as delivery vehicles. Future trending topics will concern nanomedicine challenges and technology-related applications, with a special attention toward the orientation and ordering of mesophase-separated morphologies.
在本系统综述中，对1952年至2019年间发表的共计45143篇关于嵌段共聚物的出版物，从数量、来源、语言、机构、国家、关键词和嵌段共聚物类型等方面进行了分析，以了解其发展历程并预测研究趋势。六十多年来，关于嵌段共聚物的出版物数量一直在增长，在过去几年中保持着稳定的水平。这些文献大多来自美国，不过最近中国机构的发文量最大。关键词分析表明，三分之一的出版物涉及合成，约20%探讨了自组装和形态学方面，另有20%涉及嵌段共聚物在溶液中的应用。特别是，2019年证实了与药物递送相关的研究有所扩展，在较小程度上，也涉及对自组装更深入的研究。苯乙烯-丁二烯-苯乙烯嵌段共聚物在基础研究和工业导向研究中都是最受欢迎的。其他受到高度研究的共聚物是聚环氧乙烷-聚环氧丙烷-聚环氧乙烷（普朗尼克©）以及基于聚己内酯或聚乳酸的两亲性嵌段共聚物，它们的成功归功于其作为递送载体的潜力。未来的热门话题将涉及纳米医学挑战和技术相关应用，特别关注中间相分离形态的取向和有序性。
