LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.
Molecules. 2020 Apr 10;25(7):1744. doi: 10.3390/molecules25071744.
Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix. In this work, PLGA and PEG polymers were functionalized with coumarin and carbohydrate moieties such as thymidine, glucose, galactose, and mannose that have high biological specificities. Using a single oil in water emulsion methodology, functionalized PLGA nanoparticles were prepared having a smooth surface and sizes ranging between 114-289 nm, a low polydispersity index and a zeta potential from -28.2 to -56.0 mV. However, for the corresponding PEG derivatives the polymers obtained were produced in the form of films due to the small size of the hydrophobic core.
聚合物纳米粒子可用于医疗保健中的药物输送系统。为此，聚（乳酸-共-乙醇酸）（PLGA）和聚（乙二醇）（PEG）提供了极好的聚合物基质。在这项工作中，PLGA 和 PEG 聚合物用香豆素和具有高生物特异性的碳水化合物部分（如胸苷、葡萄糖、半乳糖和甘露糖）进行了功能化。使用单一的油包水乳液方法，制备了具有光滑表面和尺寸在 114-289nm 之间、低多分散指数和zeta 电位在-28.2 到-56.0mV 之间的功能化 PLGA 纳米粒子。然而，对于相应的 PEG 衍生物，由于疏水性核心较小，所得到的聚合物以薄膜形式存在。
