Silant'ev Vladimir E, Shmelev Mikhail E, Belousov Andrei S, Patlay Aleksandra A, Shatilov Roman A, Farniev Vladislav M, Kumeiko Vadim V
Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690922 Vladivostok, Russia.
Laboratory of Electrochemical Processes, Institute of Chemistry, FEB RAS, 690022 Vladivostok, Russia.
Polymers (Basel). 2023 May 30;15(11):2516. doi: 10.3390/polym15112516.
Brain tumors are the most difficult to treat, not only because of the variety of their forms and the small number of effective chemotherapeutic agents capable of suppressing tumor cells, but also limited by poor drug transport across the blood-brain barrier (BBB). Nanoparticles are promising drug delivery solutions promoted by the expansion of nanotechnology, emerging in the creation and practical use of materials in the range from 1 to 500 nm. Carbohydrate-based nanoparticles is a unique platform for active molecular transport and targeted drug delivery, providing biocompatibility, biodegradability, and a reduction in toxic side effects. However, the design and fabrication of biopolymer colloidal nanomaterials have been and remain highly challenging to date. Our review is devoted to the description of carbohydrate nanoparticle synthesis and modification, with a brief overview of the biological and promising clinical outcomes. We also expect this manuscript to highlight the great potential of carbohydrate nanocarriers for drug delivery and targeted treatment of gliomas of various grades and glioblastomas, as the most aggressive of brain tumors.
脑肿瘤是最难治疗的，这不仅是因为它们形式多样，而且能够抑制肿瘤细胞的有效化疗药物数量少，还受到药物穿过血脑屏障（BBB）能力差的限制。纳米颗粒是纳米技术发展推动的有前景的药物递送解决方案，出现在1至500纳米范围内材料的创造和实际应用中。基于碳水化合物的纳米颗粒是用于活性分子运输和靶向药物递送的独特平台，具有生物相容性、可生物降解性，并能减少毒副作用。然而，生物聚合物胶体纳米材料的设计和制造迄今为止一直且仍然极具挑战性。我们的综述致力于描述碳水化合物纳米颗粒的合成和修饰，并简要概述其生物学和有前景的临床结果。我们还期望这篇稿件能够突出碳水化合物纳米载体在药物递送以及针对各级胶质瘤和胶质母细胞瘤（最具侵袭性的脑肿瘤）进行靶向治疗方面的巨大潜力。
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