Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Nutrients. 2020 Apr 10;12(4):1045. doi: 10.3390/nu12041045.
Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though the known benefits of an exclusive mother's own milk diet in early life have been well recognized and described, it is less understood how breastfed infants enjoy a potential reduction in risk of LOS and other systemic infections. Here we review how gut residing pathogens within the intestinal microbiota of infants can cause a subset of sepsis cases and the components of breastmilk that may prevent the dissemination of pathogens from the intestine.
晚发型败血症（LOS）和其他全身血流感染是新生儿死亡的显著原因，尤其是在早产儿极低出生体重儿中。生命早期的母乳喂养有许多健康益处，会影响新生儿的短期和长期健康。虽然人们已经充分认识到并描述了生命早期纯母乳喂养的已知益处，但人们对母乳喂养婴儿如何降低 LOS 和其他全身感染风险的了解较少。在这里，我们回顾了婴儿肠道微生物群中肠道定植病原体如何引起部分败血症病例，以及母乳中的哪些成分可能阻止病原体从肠道传播。
