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哪些患者在全髋关节置换术后改善最大?荷兰关节置换登记处 22357 例全髋关节置换术后患者报告的结局测量指标中患者特征的影响。

Which patients improve most after total hip arthroplasty? Influence of patient characteristics on patient-reported outcome measures of 22,357 total hip arthroplasties in the Dutch Arthroplasty Register.

机构信息

Orthopaedic Surgery Department, Medical Center Leeuwarden, Leeuwarden, The Netherlands.

Orthopaedic Surgery Department, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

出版信息

Hip Int. 2021 Sep;31(5):593-602. doi: 10.1177/1120700020913208. Epub 2020 Apr 14.

Abstract

BACKGROUND

Patient-reported outcome measures (PROMs) after total hip arthroplasty (THA), can be influenced by patient characteristics (case-mix factors). We used the Dutch Arthroplasty Register (LROI) to determine the effect of case-mix on improvement of PROMs after primary THA.

METHODS

We included all primary THAs ( = 22,357) performed in the Netherlands between 2014 and 2018. The Hip disability and Osteoarthritis Outcome Score Physical function short form (HOOS-PS), Oxford Hip Score (OHS), EQ-5D index score and thermometer, and Numeric Rating Scales (NRS) measuring pain during activities and at rest, were recorded. The difference between preoperative and 3- and 12-month postoperative scores was calculated (delta-PROM) and used as primary outcome variable. Multivariable linear regression was used to examine the association between patient characteristics (age, sex, ASA score, body mass index (BMI), Charnley class, smoking, and previous operations to the affected hip) and PROMs. Cohens' d was used to measure effect size.

RESULTS

Postoperative improvement (delta-PROM) on HOOS-PS, OHS, EQ-5D, and pain relief were significantly higher in patients <60 years, in patients with female gender, a high ASA score (III-IV), a BMI >30 kg/m, and patients without a previous operation to the hip. Cohen's d indicated clinically small differences (0.2).

CONCLUSIONS

Patients benefiting most in terms of postoperative improvement of self-reported physical functioning, pain relief and quality of life after primary THA were young, female, with a high ASA or BMI score, and without previous operations to the hip.

摘要

背景

全髋关节置换术(THA)后的患者报告结局测量(PROMs)可能受到患者特征(病例组合因素)的影响。我们使用荷兰关节置换登记处(LROI)来确定病例组合对初次 THA 后 PROM 改善的影响。

方法

我们纳入了 2014 年至 2018 年期间在荷兰进行的所有初次 THA(共 22,357 例)。使用髋关节残疾和骨关节炎结局评分(HOOS-PS)、牛津髋关节评分(OHS)、EQ-5D 指数评分和温度计以及用于测量活动时和休息时疼痛的数字评分量表(NRS)进行评估。计算术前与术后 3 个月和 12 个月的评分差值(PROM 差值)作为主要结局变量。采用多变量线性回归分析患者特征(年龄、性别、ASA 评分、体重指数(BMI)、Charnley 分级、吸烟和髋关节既往手术)与 PROMs 的关系。使用 Cohen's d 来衡量效应大小。

结果

HOOS-PS、OHS、EQ-5D 和疼痛缓解的术后改善(PROM 差值)在年龄<60 岁、女性、ASA 评分较高(III-IV)、BMI>30kg/m2 和髋关节无既往手术的患者中显著更高。Cohen's d 表明存在临床小差异(0.2)。

结论

在初次 THA 后,自我报告的身体功能、疼痛缓解和生活质量方面术后改善获益最大的患者是年轻、女性、ASA 或 BMI 评分较高且髋关节无既往手术的患者。

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