大蒜提取物在假体相关感染中的应用：文献综述。
Garlic extract in prosthesis-related infections: a literature review.
机构信息
The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.
Department of Orthopaedics, Yichuan People's Hospital, Luoyang, Henan Province, China.
出版信息
J Int Med Res. 2020 Apr;48(4):300060520913778. doi: 10.1177/0300060520913778.
Abstract
With the increasing use of joint replacement surgery, the prevalence of periprosthetic joint infections (PJI) has also increased. However, treating PJI has become a challenge for orthopaedic surgeons because of the prevalence of multi-drug resistant (MDR) bacteria and the formation of protective biofilms. Numerous studies have shown that garlic extract (GE) has antibacterial activities and might be a good candidate for PJI treatment. This review explores the antibacterial and antibiofilm activities of GE and its potential to be used in the treatment of PJI.
摘要
随着关节置换手术的日益普及，人工关节周围感染（PJI）的患病率也有所增加。然而，由于多药耐药（MDR）细菌的流行和保护性生物膜的形成，治疗 PJI 已成为骨科医生面临的挑战。许多研究表明，大蒜提取物（GE）具有抗菌活性，可能是治疗 PJI 的一个很好的候选药物。本综述探讨了 GE 的抗菌和抗生物膜活性及其在治疗 PJI 中的潜在应用。
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