School of Public Health, Curtin University, Perth, WA, Australia.
School of Social Sciences, The University of Queensland, Brisbane, QLD, Australia.
Child Psychiatry Hum Dev. 2021 Feb;52(1):77-95. doi: 10.1007/s10578-020-00989-4.
Inconsistent results of the association between severe psychiatric disorders (SPD) in parents and the risk of disruptive behavioral disorders (DBD) including conduct disorders (CD) and oppositional defiant disorders (ODD) in the offspring have been found by previous epidemiologic studies. PubMed, EMBASE, PsycINFO, and Scopus were searched for relevant studies. Fourteen studies met the predefined criteria for inclusion. A meta-analysis of the included studies revealed an elevated risk of DBD in the offspring of parents with SPD, bipolar, and depressive disorders. Our further analysis considering the specific DBD as an outcome showed that parents with SPD are at an increased risk of having a child with ODD as well as CD. Moreover, the current meta-analysis found that the children of parents with bipolar disorder were also at increased risk of ODD and CD. Parental schizophrenia and depressive disorders were not associated with higher risks of ODD and CD in the offspring.
先前的流行病学研究发现，父母严重精神障碍 (SPD) 与子女破坏性行为障碍 (DBD) 包括品行障碍 (CD) 和对立违抗性障碍 (ODD) 风险之间的关联结果不一致。在 PubMed、EMBASE、PsycINFO 和 Scopus 中搜索了相关研究。14 项研究符合纳入标准。对纳入研究的荟萃分析显示，父母患有 SPD、双相和抑郁障碍的子女患 DBD 的风险增加。我们进一步分析了特定 DBD 的结果，发现 SPD 父母的孩子患 ODD 和 CD 的风险增加。此外，目前的荟萃分析发现，父母患有双相障碍的孩子患 ODD 和 CD 的风险也增加。父母的精神分裂症和抑郁症与子女患 ODD 和 CD 的风险增加无关。
